Studies | Pepdox

Prevention of sinonasal inflammation by a synthetic glycosaminoglycan.

International forum of allergy & rhinology|2017|Pulsipher A et al.

BACKGROUND: Glycosaminoglycans (GAGs) are polysaccharides that are distributed on respiratory epithelial cells, endothelial cells, and submucosal glands. Uniquely positioned, certain GAGs exhibit anti-inflammatory properties in respiratory diseases a…

Animal StudyLL-37

PMID: 27863138

Classical β-Lactamase Inhibitors Potentiate the Activity of Daptomycin against Methicillin-Resistant Staphylococcus aureus and Colistin against Acinetobacter baumannii.

Antimicrobial agents and chemotherapy|2017|Sakoulas G et al.

We asked whether beta-lactamase inhibitors (BLIs) increased the activity of daptomycin (DAP) against methicillin-resistant Staphylococcus aureus (MRSA), the peptide antibiotic colistin (COL) against the emerging Gram-negative nosocomial pathogen Acin…

Anti-fungal activity of Ctn[15-34], the C-terminal peptide fragment of crotalicidin, a rattlesnake venom gland cathelicidin.

The Journal of antibiotics|2017|Cavalcante C et al.

Crotalicidin (Ctn), a 34-residue cathelicidin from a South American rattlesnake, and its fragment (Ctn[15-34]) have shown anti-infective and cytotoxic activities against Gram-negative bacteria and certain tumor lines, respectively. The extent of such…

In VitroLL-37

PMID: 27876749

The Critical and Multifunctional Roles of Antimicrobial Peptides in Dermatology.

Dermatologic clinics|2017|Takahashi T, Gallo R

Antimicrobial peptides are central effector molecules in skin immunology. The functions of antimicrobial peptides in skin diseases include the ability to act as cytokines or growth factors, driving disorders such as psoriasis and rosacea, as well as…

ReviewLL-37

PMID: 27890236

A short history of phototherapy, vitamin D and skin disease.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology|2017|Jarrett P, Scragg R

The earliest record between sun exposure and skin disease goes back five millennia to the ancient Egyptians. The modern scientific era of medical light therapy and skin diseases started in 1877 when Downs and Blunt reported that exposure to light inh…

Animal StudyLL-37

PMID: 27892584

TRPV4 Mediates Mast Cell Activation in Cathelicidin-Induced Rosacea Inflammation.

The Journal of investigative dermatology|2017|Mascarenhas N et al.

LL-37

PMID: 27908695

Cathelicidin (LL-37) level in the scalp hair of patients with tinea capitis.

Medical mycology|2017|Abdelaal N et al.

Antimicrobial peptides (AMPs) are considered an important first line of defense against pathogens. Cathelicidin LL-37 was upregulated in response to fungal infection. In this work we aimed to evaluate cathelicidin LL-37 in the hair of tinea capitis a…

LL-37

PMID: 27915299

Antimicrobial peptide LL-37 promotes YB-1 expression, and the viability, migration and invasion of malignant melanoma cells.

Molecular medicine reports|2017|Jia J et al.

The cathelicidin antimicrobial peptide, LL-37, is a multifunctional peptide with a broad spectrum of antimicrobial activities, such as chemotaxis and neutralizing endotoxins. Previous studies have demonstrated that it LL‑37 serves a functional role i…

LL-37

PMID: 27922666

Positive selection in cathelicidin host defense peptides: adaptation to exogenous pathogens or endogenous receptors?

Heredity|2017|Zhu S, Gao B

The cause of adaptive protein evolution includes internal (for example, co-evolution of ligand-receptor pairs) and external (for example, adaptation to different ecological niches) mechanisms. Host defense peptides (HDPs) are a class of vertebrate-sp…

Animal StudyLL-37

PMID: 27925615

Pathological Role and Diagnostic Value of Endogenous Host Defense Peptides in Adult and Neonatal Sepsis: A Systematic Review.

Shock (Augusta, Ga.)|2017|Ho J et al.

BACKGROUND: Sepsis is a systemic host response to an infection leading to organ failure. This is associated with dynamic expression of endogenous host defense peptides. Dysregulation of these peptides is associated with septic morbidity and mortality…

ReviewAnimal StudyIn VitroLL-37

PMID: 27941592

The relation of innate and adaptive immunity with viral-induced acute asthma attacks: Focusing on IP-10 and cathelicidin.

Allergologia et immunopathologia|2017|Arikoglu T et al.

BACKGROUND: Despite growing evidence suggesting potential association between innate and adaptive immunity in viral-induced acute asthma, there is paucity of data in this area. OBJECTIVE: This study aimed to investigate the association of innate and…

LL-37

PMID: 27955890

Cutting Edge: LL-37-Mediated Formyl Peptide Receptor-2 Signaling in Follicular Dendritic Cells Contributes to B Cell Activation in Peyer's Patch Germinal Centers.

Journal of immunology (Baltimore, Md. : 1950)|2017|Kim S, Kim Y, Jang Y

Peyer's patches (PPs) are the major mucosal immune-inductive site, and germinal centers (GCs) in PPs determine the quality of the Abs produced. PP GCs are continuously induced by the gut microbiota, and their maintenance contributes to the induction…

LL-37

PMID: 27974458

Mirolysin, a LysargiNase from Tannerella forsythia, proteolytically inactivates the human cathelicidin, LL-37.

Biological chemistry|2017|Koneru L et al.

Tannerella forsythia is a periodontal pathogen expressing six secretory proteolytic enzymes with a unique multidomain structure referred to as KLIKK proteases. Two of these proteases, karilysin and mirolysin, were previously shown to protect the bact…

LL-37

PMID: 27997347

Gene electrotransfer into skin using noninvasive multi-electrode array for vaccination and wound healing.

Bioelectrochemistry (Amsterdam, Netherlands)|2017|Kos S et al.

Skin is an attractive target for gene electrotransfer due to its easy accessibility and its interesting immune properties. Since electrodes are often invasive and frequently induce discomfort during pulse application, there is a fundamental need for…

Animal StudyLL-37

PMID: 28006672

The host defense peptide LL-37 a possible inducer of the type I interferon system in patients with polymyositis and dermatomyositis.

Journal of autoimmunity|2017|Lu X et al.

The type I interferon (IFN) system has recently been suggested to play important and essential roles in the pathogenesis of myositis. However, a clarification of how type I IFNs could function as triggering factor(s) in the pathogenesis of myositis h…

LL-37

PMID: 28012697

Assays for Identifying Inducers of the Antimicrobial Peptide LL-37.

Methods in molecular biology (Clifton, N.J.)|2017|Nylén F et al.

One promising approach to meet the growing problem of antibiotic resistance is to modulate host defense mechanisms, i.e., host-directed therapy (HDT), in the fight against infections. Induction of endogenous antimicrobial peptides (AMPs) via small mo…

LL-37

PMID: 28013511

Collagen tethering of synthetic human antimicrobial peptides cathelicidin LL37 and its effects on antimicrobial activity and cytotoxicity.

Acta biomaterialia|2017|Lozeau L et al.

UNLABELLED: Wound infections, particularly of chronic wounds, pose a substantial challenge for designing antimicrobial dressings that are both effective against pathogens, and do not interfere with wound healing. Due to their broad-spectrum antimicro…

LL-37

PMID: 28017866

miR-663a regulates growth of colon cancer cells, after administration of antimicrobial peptides, by targeting CXCR4-p21 pathway.

BMC cancer|2017|Kuroda K et al.

BACKGROUND: Antimicrobial peptides (AMPs) play important roles in the innate immune system of all life forms and recently have been characterized as multifunctional peptides that have a variety of biological roles such as anticancer agents. However,…

Animal StudyIn VitroLL-37

PMID: 28061765

Cathelicidin-WA Improves Intestinal Epithelial Barrier Function and Enhances Host Defense against Enterohemorrhagic Escherichia coli O157:H7 Infection.

Journal of immunology (Baltimore, Md. : 1950)|2017|Yi H et al.

Impaired epithelial barrier function disrupts immune homeostasis and increases inflammation in intestines, leading to many intestinal diseases. Cathelicidin peptides suppress intestinal inflammation and improve intestinal epithelial barrier function…

Animal StudyIn VitroLL-37

PMID: 28062699

The random co-polymer glatiramer acetate rapidly kills primary human leukocytes through sialic-acid-dependent cell membrane damage.

Biochimica et biophysica acta. Biomembranes|2017|Christiansen S et al.

The formulation glatiramer acetate (GA) is widely used in therapy of multiple sclerosis. GA consists of random copolymers of four amino acids, in ratios that produce a predominantly positive charge and an amphipathic character. With the extraordinary…

LL-37

PMID: 28064019