The only human cathelicidin antimicrobial peptide, playing key roles in innate immune defense, wound healing, and modulation of inflammatory responses.
ACS applied bio materials|2026|Li C et al.
To combat the growing challenge of bacterial infections, sonodynamic antibacterial technology has gained increasing attention. However, current approaches still face limitations, including suboptimal efficacy and a narrow antibacterial spectrum (only…
PMID: 41805322
Research square|2026|Wu Y et al.
The fever response is triggered during infection and inflammation, but the importance of this response for the function of antimicrobial peptides (AMPs) remains unknown. We discovered that the activity of the human AMP LL-37 is temperature-dependent…
PMID: 41674812
Research in veterinary science|2026|Viora L et al.
Prevention and treatment of intramammary infections (IMI) associated with subclinical mastitis (SCM) are among the leading reasons for antimicrobial usage (AMU) in dairy cows, especially at dry-off. By adopting a selective dry cow therapy ((S)DCT), o…
PMID: 41905028
Glycobiology|2026|Le Fournis C et al.
The human antimicrobial peptide LL-37 exerts a dual role in cancer, promoting tumor progression in breast carcinoma by stimulating calcium influx and enhancing cell migration. Its interactions with glycosaminoglycans (GAGs) provide an attractive ther…
PMID: 41674152
Frontiers in immunology|2026|Al-Mamari W et al.
There is an urgent need for new antimicrobial agents to address the emerging antimicrobial resistance and the lack of novel antibiotics on the market. Antimicrobial peptides (AMPs) have gained significant interest as potential antibiotics over the pa…
PMID: 41659852
The journal of physical chemistry. B|2026|Mitra A, Paul S
Cross-α amyloids are an emerging class of functional peptide assemblies that underlie biofilm formation and antibiotic resistance in bacteria. Beyond their biological significance, synthetic cross-α architectures exhibit remarkable rigidity and piezo…
PMID: 41665928
International journal of molecular sciences|2026|Fouani M et al.
Transient receptor potential vanilloid 4 (TRPV4) is a polymodal cation channel that is widely expressed in sensory neurons, immune cells, and structural tissues, where it integrates mechanical, osmotic, and chemical stimuli to regulate both physiolog…
Review
PMID: 41898724
Molecular immunology|2026|He J et al.
OBJECTIVE: This study aimed to elucidate the molecular mechanisms through which CXCL2 contributes to the pathogenesis of idiopathic interstitial pneumonia (IIP). METHODS: Neutrophils were isolated, and the formation of neutrophil extracellular traps…
Animal Study
PMID: 41443150
Biochemical pharmacology|2026|Zhang P et al.
Cathelicidins are crucial antimicrobial peptides (AMPs) that play a key role in the innate immunity of marine vertebrates. The pygmy sperm whale (Kogia breviceps), which resides in environments populated by diverse microbial communities, faces comple…
Animal Study
PMID: 41506548
Frontiers in immunology|2026|Plem R et al.
BACKGROUND: During the COVID-19 pandemic, it became evident that an infection with SARS-CoV-2 is associated with an increased predisposition for thrombembolic events. Recent studies suggest an excessive neutrophil extracellular trap (NET)-formation i…
PMID: 41694343
Frontiers in immunology|2026|Xu J et al.
BACKGROUND: Rosacea is a chronic inflammatory skin disease, with LL-37 driving inflammation. Inhibiting serine protease kallikrein-5 (KLK5) overactivity can reduce LL-37 production, thereby relieving this inflammation. Lithospermic acid (LA), a plant…
Animal Study
PMID: 41668756
ImmunoTargets and therapy|2026|Xie Y et al.
BACKGROUND: The expression of transient receptor potential vanilloid (TRPV) and Toll-like receptor 2 (TLR2) in the lesion sites of patients with rosacea is increased. Ultraviolet B (UVB) radiation can induce inflammation of keratinocytes in patients…
PMID: 41809119
Frontiers in immunology|2026|Schröder Alvarez L et al.
INTRODUCTION: Activated polymorphonuclear neutrophils (PMN) release neutrophil extracellular traps (NETs) composed of a web-like DNA core, concomitant with nuclear histones, granular peptides and enzymes. NETs in human urine and their potential role…
PMID: 41918743
Fish & shellfish immunology|2026|Jayathilaka E et al.
Bacterial extracellular vesicles (BEVs) serve as efficient drug-delivery vehicles for bioactive molecules including antimicrobial peptides (AMPs). In the present study, human cathelicidin-derived AMP LL37 was encapsulated in Streptococcus parauberis-…
Animal Study
PMID: 41205784
European journal of medicinal chemistry|2026|Asmamaw D et al.
The increasing prevalence of multidrug-resistant (MDR) bacterial infections poses global health challenges, highlighting the urgent need for new antimicrobial agents. The key advantages of antimicrobial peptides are their ability to rapid bactericida…
Animal Study
PMID: 41485275
Antiviral research|2026|Chai F et al.
Despite causing fatal encephalitis and long-term neurological, cognitive, and behavioral impairments in survivors, no antiviral drugs are currently available to treat Japanese encephalitis virus (JEV) infections, highlighting the urgent need for effe…
Animal Study
PMID: 41941993
Nutrients|2026|Caliman-Sturdza O et al.
Vitamin D is a secosteroid hormone traditionally recognized for its role in bone and mineral metabolism, but it is increasingly understood to also function as an important immunomodulator influencing susceptibility to and outcomes of infectious disea…
Review
PMID: 41754151
BMC veterinary research|2026|Liang Z et al.
BACKGROUND: Immune system is regulated by circadian rhythms, which promote inflammation and facilitate pathogen elimination. Antimicrobial peptides secreted by milk somatic cells and mammary gland epithelial cells play a crucial role in protecting th…
PMID: 41923233
Molecules (Basel, Switzerland)|2026|Lu J et al.
The appearance of antibiotic-resistant strains of() is leading to a decreased eradication rate ofinfection. There is an urgent need to find new agents with antimicrobial mechanisms different from those of antibiotics, with therapeutic potential to cl…
PMID: 41900101
International journal of molecular sciences|2026|Gambadauro A et al.
Bronchopulmonary dysplasia (BPD) is a chronic lung condition in preterm infants characterized by impaired alveolar development, disrupted vascular growth, and persistent inflammation. These alterations, which often arise from early exposure to mechan…
Review
PMID: 41683842