Studies | Pepdox

Differential protein expression in the secretory fluids of maxillary sinusitis and maxillary retention cyst.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery|2017|Kim S et al.

Both maxillary sinusitis (MS) and maxillary retention cyst (MRC) involve the maxillary sinus and show similar clinical features. Clinically, differentiating between MS and MRC is sometimes difficult in asymptomatic patients, despite their quite diffe…

LL-37

PMID: 27422628

Neutrophil extracellular trap formation in the Streptococcus suis-infected cerebrospinal fluid compartment.

Cellular microbiology|2017|de Buhr N et al.

Streptococcus suis is an important meningitis-causing pathogen in pigs and humans. Neutrophil extracellular traps (NETs) have been identified as host defense mechanism against different pathogens. Here, NETs were detected in the cerebrospinal fluid (…

Animal Study

Cathelicidin-encoding Lactococcus lactis promotes mucosal repair in murine experimental colitis.

Journal of gastroenterology and hepatology|2017|Wong C et al.

BACKGROUND AND AIM: The preventive effect of intrarectal administration of mouse cathelicidin (mCRAMP) and oral administration of mCRAMP-encoding Lactococcus lactis (N4I) has been shown in murine experimental colitis. It is pivotal to understand the…

Animal StudyIn VitroLL-37

PMID: 27470075

Pathogenesis of antimicrobial peptides LL-37 and CpG-ODN in ANCA associated vasculitis.

Journal of nephrology|2017|Luan J, Xing G

OBJECTIVES: Anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitides (AAV) are a group of systemic autoimmune disorders characterized by necrotizing inflammation of small- to medium-sized blood vessels. The pathogenesis of patients with…

In VitroLL-37

PMID: 27476166

Nucleases from Prevotella intermedia can degrade neutrophil extracellular traps.

Molecular oral microbiology|2017|Doke M et al.

Periodontitis is an inflammatory disease caused by periodontal bacteria in subgingival plaque. These bacteria are able to colonize the periodontal region by evading the host immune response. Neutrophils, the host's first line of defense against infec…

LL-37

PMID: 27476978

Functions of Antimicrobial Peptides in Vertebrates.

Current protein & peptide science|2017|Avila E

OBJECTIVE: The aim of this review is to examine the multiple activities of antimicrobial peptides (AMPs) in vertebrates. CONTENT: The largest AMP families are the cathelicidins and defensins, but several peptides derived from bigger proteins have als…

ReviewLL-37

PMID: 27526932

Differences in Cytokine Production during Aging and Its Relationship with Antimicrobial Peptides Production.

Immunological investigations|2017|Castañeda-Delgado J et al.

Aging is a major health issue due to the increased susceptibility of elderly people to infectious, autoimmune, and cardiovascular diseases. Innate immunity is an important mechanism to avoid primary infections; therefore, decreasing of its activity m…

LL-37

PMID: 27618158

Vitamin D Deficiency in Human and Murine Sepsis.

Critical care medicine|2017|Parekh D et al.

OBJECTIVES: Vitamin D deficiency has been implicated as a pathogenic factor in sepsis and ICU mortality but causality of these associations has not been demonstrated. To determine whether sepsis and severe sepsis are associated with vitamin D deficie…

Animal StudyLL-37

PMID: 27632669

Chronic moderate ethanol intake differentially regulates vitamin D hydroxylases gene expression in kidneys and xenografted breast cancer cells in female mice.

The Journal of steroid biochemistry and molecular biology|2017|García-Quiroz J et al.

Factors affecting vitamin D metabolism may preclude anti-carcinogenic effects of its active metabolite calcitriol. Chronic ethanol consumption is an etiological factor for breast cancer that affects vitamin D metabolism; however, the mechanisms under…

Animal StudyLL-37

PMID: 27639478

Antimicrobial peptide exposure selects for Staphylococcus aureus resistance to human defence peptides.

The Journal of antimicrobial chemotherapy|2017|Kubicek-Sutherland J et al.

BACKGROUND: The clinical development of antimicrobial peptides (AMPs) is currently under evaluation to combat the rapid increase in MDR bacterial pathogens. However, many AMPs closely resemble components of the human innate immune system and the rami…

Animal StudyIn VitroLL-37

PMID: 27650186

LL-37 but Not 25-Hydroxy-Vitamin D Serum Level Correlates with Healing of Venous Leg Ulcers.

Archivum immunologiae et therapiae experimentalis|2017|Krejner A, Litwiniuk M, Grzela T

Human cathelicidin, LL-37, is small antimicrobial peptide, which reveals also some immunomodulatory and proangiogenic properties and, therefore, may promote wound healing. The expression of LL-37 is controlled by various factors, including vitamin D.…

LL-37

PMID: 27663530

The immune modulatory peptide FhHDM-1 secreted by the helminth Fasciola hepatica prevents NLRP3 inflammasome activation by inhibiting endolysosomal acidification in macrophages.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology|2017|Alvarado R et al.

The NLRP3 inflammasome is a multimeric protein complex that controls the production of IL-1β, a cytokine that influences the development of both innate and adaptive immune responses. Helminth parasites secrete molecules that interact with innate immu…

LL-37

PMID: 27682204

Oral spray wintertime vitamin Dsupplementation has no impact on inflammation in Gaelic footballers.

Scandinavian journal of medicine & science in sports|2017|Todd J et al.

Vitamin D inadequacy [total 25(OH)D <50 nmol/L] is widespread in athletes. The biologically active metabolite, 1,25-dihydroxyvitamin D, may be involved in regulating inflammation although in vitro findings have not been consistently replicated in hum…

Randomized Controlled TrialLL-37

PMID: 27704631

Pyrazole derived ultra-short antimicrobial peptidomimetics with potent anti-biofilm activity.

European journal of medicinal chemistry|2017|Ahn M et al.

In this study, we report on the first chemical synthesis of ultra-short pyrazole-arginine based antimicrobial peptidomimetics derived from the newly synthesized N-alkyl/aryl pyrazole amino acids. Through the systematic tuning of hydrophobicity, charg…

LL-37

PMID: 27718471

Palmoplantar pustular psoriasis (PPPP) is characterized by activation of the IL-17A pathway.

Journal of dermatological science|2017|Bissonnette R et al.

BACKGROUND: Palmoplantar pustular psoriasis (PPPP) is a variant of psoriasis, which has significant negative impact on quality of life. The cellular and molecular inflammatory pathways involved in PPPP have not been well studied. OBJECTIVE: Study the…

LL-37

PMID: 27743912

TLN-58, an Additional hCAP18 Processing Form, Found in the Lesion Vesicle of Palmoplantar Pustulosis in the Skin.

The Journal of investigative dermatology|2017|Murakami M et al.

We previously reported that the early vesicle of the palmoplantar pustulosis (PPP) vesicle originated from eccrine sweat in the acrosyringium and that the PPP vesicle contains the antimicrobial peptide human cathelicidin-18/LL-37. The concentration o…

LL-37

PMID: 27771329

A preliminary study of new single polymorphisms in the T helper type 17 pathway for psoriasis in the Korean population.

Clinical and experimental immunology|2017|Kim S et al.

Psoriasis is a polygenic and multi-factorial disease showing ethnic differences in terms of its severity and frequency. Therapies targeting interleukin (IL)-17A, IL-17 receptor (IL-17R) and Janus kinases (JAKs) are in clinical development for the tre…

LL-37

PMID: 27774581

Vitamin D increases the antiviral activity of bronchial epithelial cells in vitro.

Antiviral research|2017|Telcian A et al.

BACKGROUND: By modulating the antiviral immune response via vitamin D receptor, the active form of vitamin D (1,25-dihydroxyvitamin D, calcitriol) could play a central role in protection against respiratory virus infections. This in vitro study teste…

LL-37

PMID: 27838350

Serum cathelicidin, nasopharyngeal microbiota, and disease severity among infants hospitalized with bronchiolitis.

The Journal of allergy and clinical immunology|2017|Hasegawa K et al.

LL-37

PMID: 27845236

Collectins, H-ficolin and LL-37 reduce influence viral replication in human monocytes and modulate virus-induced cytokine production.

Innate immunity|2017|White M et al.

Infiltrating activated monocytes are important mediators of damaging inflammation during influenza A virus (IAV) infection. We show that soluble respiratory proteins [collectins, surfactant proteins D (SP-D) and mannose binding lectin (MBL), H-ficoli…

LL-37

PMID: 27856789