Studies | Pepdox

Salivary Levels of Antimicrobial Peptides in Chronic Periodontitis Patients with Type 2 Diabetes.

Journal of the International Academy of Periodontology|2019|Zainab A, Ashish N, Ragnath V|4 citations

OBJECTIVE: The aim of this study was to evaluate the interrelationship between salivary levels of human neutrophil antimicrobial peptides (AMP) 1-3 (HNP 1-3), LL-37 and periodontitis in individuals with and without type 2 diabetes (T2DM). METHODS: Ei…

LL-37

PMID: 31522161

Sputum microbiota and inflammation at stable state and during exacerbations in a cohort of chronic obstructive pulmonary disease (COPD) patients.

PloS one|2019|Tangedal S et al.|28 citations

BACKGROUND: Exacerbations of chronic obstructive pulmonary disease (COPD) are debilitating events and spur disease progression. Infectious causes are frequent; however, it is unknown to what extent exacerbations are caused by larger shifts in the air…

Immunomodulatory Functions of the Human Cathelicidin LL-37 (aa 13-31)-Derived Peptides are Associated with Predicted α-Helical Propensity and Hydrophobic Index.

Biomolecules|2019|Hemshekhar M et al.|13 citations

The anti-endotoxin activity of the cationic peptide LL-37 and its derivative IG-19 is attributed to electrostatic interaction of the peptides' positive charge with negatively charged bacterial lipopolysaccharides (LPS), and in part to the alteration…

LL-37

PMID: 31540479

Sulfated Glycoaminoglycans and Proteoglycan Syndecan-4 Are Involved in Membrane Fixation of LL-37 and Its Pro-Migratory Effect in Breast Cancer Cells.

Biomolecules|2019|Habes C, Weber G, Goupille C|21 citations

Initially characterized by its antimicrobial activities, LL-37 has also been shown to significantly contribute to tumor development. On breast cancer cell lines, LL-37 increases intracellular calcium via the TRPV2 channel and their migration via the…

LL-37

PMID: 31547381

Differentiating Asymptomatic Bacteriuria From Urinary Tract Infection in the Pediatric Neurogenic Bladder Population: NGAL As a Promising Biomarker.

Topics in spinal cord injury rehabilitation|2019|Gupta S et al.|13 citations

To evaluate whether urinary antimicrobial peptides (AMPs) can discriminate between asymptomatic bacteriuria (ASB) and urinary tract infection (UTI) in pediatric patients with neurogenic bladder (NGB).Bladder urine was collected from pediatric patient…

LL-37

PMID: 31548788

Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes.

PloS one|2019|Gonzalez S et al.|14 citations

INTRODUCTION: Mucosal immune activation, in the context of sexual transmission of HIV-1 infection, is crucial, as the increased presence of activated T cells enhance susceptibility to infection. In this regard, it has been proposed that immunomodulat…

In VitroLL-37

PMID: 31550271

Relationship Between mRNA of Immune Factors Expressed by Milk Somatic Cells and Bacteria Present in Healthy Lactating Holstein Cows.

Journal of veterinary research|2019|Ohtsuka H et al.|1 citation

INTRODUCTION: The characteristics of immune factors in somatic cells from lactating dairy cows and their association with commensal bacteria in normal milk have not been clarified. This study investigated the relationship between the pathogenic bacte…

LL-37

PMID: 31572817

Polymorphisms in the P2X7 receptor, and differential expression of Toll-like receptor-mediated cytokines and defensins, in a Canadian Indigenous group.

Scientific reports|2019|Semple C et al.|4 citations

Canadian Indigenous peoples (First Nations and Inuit) exhibit a high burden of infectious diseases including tuberculosis influenced by societal factors, and biological determinants. Toll-like receptor (TLR)-mediated innate immune responses are the f…

LL-37

PMID: 31578370

Cathelicidin-related antimicrobial peptide protects against cardiac fibrosis in diabetic mice heart by regulating endothelial-mesenchymal transition.

International journal of biological sciences|2019|Zheng X et al.|32 citations

(CRAMP), antimicrobial peptide, was reported to protect against myocardial ischemia/reperfusion injury. In the pathology of diabetic cardiomyopathy, endothelial-to-mesenchymal transition (EndMT) results from hyperglycemia-induced endothelial injury,…

Animal StudyLL-37

PMID: 31595157

Cathelicidin-Derived Synthetic Peptide Improves Therapeutic Potential of Vancomycin Against.

Frontiers in microbiology|2019|Mohammed I et al.|35 citations

(PA) is the leading cause of corneal blindness worldwide. A constant increase in multi-drug resistant PA strains have heightened the challenge of effectively managing corneal infections with conventional antibiotics. Antimicrobial peptides are promis…

LL-37

PMID: 31608030

The cysteine protease ApdS frompromotes evasion of innate immune defenses by cleaving the antimicrobial peptide cathelicidin LL-37.

The Journal of biological chemistry|2019|Xie F et al.|25 citations

is a globally distributed zoonotic pathogen associated with meningitis and septicemia in humans, posing a serious threat to public health. To successfully invade and disseminate within its host, this bacterium must overcome the innate immune system.…

LL-37

PMID: 31619521

LprE Suppresses TLR2-Dependent Cathelicidin and Autophagy Expression to Enhance Bacterial Survival in Macrophages.

Journal of immunology (Baltimore, Md. : 1950)|2019|Padhi A et al.|50 citations

Despite representing a very important class of virulence proteins, the role of lipoproteins in the pathogenesis ofremains elusive. In this study, we investigated the role of putative lipoprotein LprE in the subversion of host immune responses using t…

Animal StudyLL-37

PMID: 31619537

Association of Fok1 VDR polymorphism with Vitamin D and its associated molecules in pulmonary tuberculosis patients and their household contacts.

Scientific reports|2019|Panda S et al.|28 citations

Status of Fok I VDR polymorphism along with vitamin D, Vitamin D receptor (VDR), and cathelicidin levels in Tuberculosis (TB) patients compared to household contacts and implication of these findings in susceptibility to TB is not known. 150 active T…

LL-37

PMID: 31649297

[Clinical significance of antibacterial peptide LL-37 in early diagnosis of patients with sepsis in emergency department].

Zhonghua wei zhong bing ji jiu yi xue|2019|Liu A et al.|2 citations

OBJECTIVE: To discuss the clinical significance of antibacterial peptide LL-37 in the early diagnosis of patients with sepsis in emergency department. METHODS: Forty patients diagnosed with sepsis in the emergency department of the Affiliated Hospita…

LL-37

PMID: 31657329

Regulation of MSC and macrophage functions in bone healing by peptide LL-37-loaded silk fibroin nanoparticles on a titanium surface.

Biomaterials science|2019|He Y et al.|28 citations

Titanium-based materials have been long regarded as effective bone implants for clinical use, yet the corresponding osteointegration ability needs to be optimized. This challenge can be overcome by fabricating titanium (Ti) materials with physiologic…

Animal StudyLL-37

PMID: 31663543

The Critical Role of the Antimicrobial Peptide LL-37/ CRAMP in Protection of Colon Microbiota Balance, Mucosal Homeostasis, Anti-Inflammatory Responses, and Resistance to Carcinogenesis.

Critical reviews in immunology|2019|Zhang M et al.|23 citations

Mouse cathelin-related antimicrobial peptide (CRAMP) and its homologue human cathelicidin (LL-37) play active roles in innate immune responses, angiogenesis, and wound healing. In addition, LL-37/CRAMP fends off microbes and protects against infectio…

ReviewAnimal StudyLL-37

PMID: 31679249

Performance evaluation of antimicrobial peptide ll-37 and hepcidin and β-defensin-2 secreted by mesenchymal stem cells.

Heliyon|2019|Esfandiyari R et al.|26 citations

Peptides are secreted by different cell types and are trendy therapeutic agents that have attracted attention for the treatment of several diseases such as infections. Antimicrobial peptides exert various mechanisms such as changing cell membrane per…

ReviewLL-37

PMID: 31687504

Exposure to low-dose arsenic in early life alters innate immune function in children.

Journal of immunotoxicology|2019|Parvez F et al.|18 citations

Early-life exposure to arsenic (As) increases risks of respiratory diseases/infections in children. However, data on the ability of the innate immune system to combat bacterial infections in the respiratory tracts of As-exposed children are scarce. T…

LL-37

PMID: 31703545

Effects of cigarette smoke on barrier function and tight junction proteins in the bronchial epithelium: protective role of cathelicidin LL-37.

Respiratory research|2019|Tatsuta M et al.|108 citations

BACKGROUND: Airway epithelial barrier function is maintained by the formation of tight junctions (TJs) and adherens junctions (AJs). Inhalation of cigarette smoke causes airway epithelial barrier dysfunction and may contribute to the pathogenesis of…

LL-37

PMID: 31706310

Neutrophilic Granule Protein Is a Novel Murine LPS Antagonist.

Immune network|2019|Hong J et al.|14 citations

Neutrophilic granule protein (NGP) was previously reported as a granular protein of neutrophils in mouse, but the function has not been known clearly. We found the presence of the possible signal peptide in NGP and validated this protein is circulati…

Animal StudyLL-37

PMID: 31720045