Studies

Peptides are short chains of amino acids with a unique pharmacological niche between small-molecule drugs and large proteins. Their use in sports medicine is rapidly expanding, driven by patient demand for accelerated injury recovery and performance…

Consensus-based recommendations (CBRs) are essential for health care decision-making when evidence is limited or conflicting. They can be developed using established methodologies such as the Delphi technique, the nominal group technique (NGT), and t…

UNLABELLED: Rice microbiome plays a critical role in the growth, health, stress tolerance, nutrient uptake, root development, and productivity of its host. In this study, advanced machine learning algorithms were applied to analyze the genomic data f…

BACKGROUND: Medical thoracoscopy is a minimally invasive procedure with high diagnostic yield in undiagnosed exudative pleural effusions. There is limited data on its efficacy and safety from high-volume tertiary centers in India, considering the cha…

BACKGROUND: The ream-and-run arthroplasty (RnR) has shown to be a viable treatment option for young, active patients with shoulder osteoarthritis. However, there are notable concerns with the generalizability of these findings as much of the literatu…

UNLABELLED: Thyroid hormones modulate brain structures during neurogenesis and impact cognition and emotions during the lifetime. Hypothyroidism is commonly associated with lower gray matter volume. Fewer studies, however, highlighted significant ass…

Intrauterine growth restriction (IUGR) is a leading cause of perinatal morbidity and mortality. Oxidative stress is a key factor in the pathogenesis of IUGR. The transcription factor nuclear factor erythroid 2‑related factor 2 (Nrf2) is a key regulat…

OBJECTIVE: MOTS-c is a mitochondria-derived peptide associated with reduced insulin resistance and obesity. The m.1382A>C polymorphism of the MOTS-c gene is linked to an increased risk of type 2 diabetes in men. However, no studies have explored the…

BACKGROUND: There are no optimized patient blood management (PBM) protocols for brain tumor resection (BTR). The aim of this study was to compare the prevalence of packed red cells (PRCs) units reserved with the prevalence of transfusion during BTR a…

OBJECTIVES: Androgen and TGF-β1/Smad signaling pathways play important roles in epithelial-mesenchymal transition (EMT), fibrosis, and the development of benign prostatic hyperplasia (BPH). Cinnamophilin is extracted from. The anti-proliferative and…

BACKGROUND: Ecological stoichiometry serves as a foundational framework for understanding plant nutrient acquisition, allocation, and conservation strategies in extreme environments. The Wudalianchi volcanic lava platform represents a naturally oligo…

BACKGROUND: Primary Sjögren's disease (SjD) is a chronic autoimmune disease that predominantly affects exocrine glands but can also show numerous systemic organ manifestations. OBJECTIVE: Presentation of the current understanding of the pathogenesis…

INTRODUCTION: Excessive daytime sleepiness has traditionally been regarded as the hallmark symptom of obstructive sleep apnea (OSA), yet nearly half of individuals with OSA do not report significant sleepiness. While treatments are well established f…

In real-world settings, the incidence of diabetes remission remains low. The factors identified as being associated with diabetes remission included a short duration of diabetes, low baseline hemoglobin A1c (HbA1c) levels, absence of ongoing diabetes…

Tirzepatide, a dual GIP/GLP-1 receptor agonist, shows promise in managing obesity and type 2 diabetes. This bibliometric analysis maps its research landscape, identifying trends, collaborations, and emerging themes to guide future investigations. A s…

The effects on hepatic mitochondrial structure, mitophagy, and cellular homeostasis were investigated when treated with Tirzepatide (Tzp), a dual GIP/GLP-1 receptor agonist, in a mouse model combining obesity, type 2 diabetes, and menopause-condition…