A synthetic peptide analog of ACTH(4-10) developed in Russia, studied for nootropic, neuroprotective, and anxiolytic effects.
Semax is a synthetic analog of adrenocorticotropic hormone 4-10 with a pronounced nootropic effect. It was used in the treatment of vascular, toxic allergic, and inflammatory diseases of the optic nerve and partial atrophy of the optic nerve in paral…
The ACTH(4-7)analogue Semax administered intraperitoneally in a dose of 50 microg/kg 1 h before exposure to ulcerogenic factors (ethanol, water immersion immobilization stress) protected gastric mucosa from damage. Postoperative treatment with Semax…
Semax favorably affects ultrastructural changes in the pancreas of rats with acute pancreatitis (AP): a single introduction of semax (0.1 mg/kg) into the pancreatic duct of rats with AP model prevents increased necrosis of the acinar tissues and inhi…
Effect of a neuropeptide semax is studied in 73 patients with various symptoms of posthypoxic encephalopathy in remote period. Fourteen of these patients developed a persistent vegetative state. The therapy was effective in patients with mnestic diso…
Semax is the first domestic nootropic drug of an unexhausted type from the group of neuropeptides. In experimental studies it showed angioprotective, antihypoxic and neurotrophic activity in the doses 100-150 micrograms/kg. A combined clinical-electr…
LPO products were measured in plasma and biogenic amines (serotonin, adrenalin, noradrenalin) in tissues of rats in different periods after hemorrhagic shock provoked by taking blood and maintenance of arterial pressure at the level of 40 mm Hg for 1…
Experiments with white mongrel rats (both females and males) showed that nootropic substances, i.e. sodium hydroxybutyrate, pyracetam, oxyracetam, aniracetam, centrophinoxine, nooglutyl, mexydol, semax, amide L-pyroglutamyl-D-alanine, and MK-801, a s…
Efficiency of Semax (synthetic derivative of ACTH-4-10) was studied in 30 patients in acute period of hemispherical ischemic stroke. Control group consisted of 80 patients with the strokes analogous in severity and location of the damages and which w…
Semax is one of the rare analogues of regulatory peptides which underwent all stages from fundamental investigations to practical usage. It has been demonstrated that this peptide is capable to stimulate operative memory and attention, to increase re…
Data available in the literature and the author's own findings of the effects of regulatory peptide (RP) and their analogues are summarized. MIF, TRH, and its analog PR-546, the paraopioid RP, leuenkephalin, dalargin, the ACTH analogue Semax, tafcin,…
Experiments on rats demonstrated that the low-intensity electromagnetic field (12.6 cm, 2375 MHz, power density 1 mW/cm2), motion sickness, and electroconvulsive shock provoked the retrograde amnesia in the passive avoidance test. The oxyracetam (100…