Effect of Semax on homeostasis of gastric mucosa in albino rats.

Bulletin of experimental biology and medicine20002 citationsPMID: 11177268

Animal StudySemax

Plain Language Summary

This animal study examined Semax's effects on gastric mucosal homeostasis in albino rats. The ACTH(4-10) analog demonstrated protective effects on the gastric mucosa, suggesting gastroprotective properties that extend its known neurotrophic and neuroprotective activities.

Abstract

The ACTH(4-7)analogue Semax administered intraperitoneally in a dose of 50 microg/kg 1 h before exposure to ulcerogenic factors (ethanol, water immersion immobilization stress) protected gastric mucosa from damage. Postoperative treatment with Semax for 5 days after application of glacial acetic acid on the mucosa prevented acetic acid-induced ulcers and promoted their healing. The antiulcer effects of Semax in the studied dose were comparable with those of tripeptide Pro-Gly-Pro in a dose of 1 mg/kg.

Authors

Zhuikova, S E; Smirnova, E A; Bakaeva, Z V; Samonina, G E; Ashmarin, I P