The only human cathelicidin antimicrobial peptide, playing key roles in innate immune defense, wound healing, and modulation of inflammatory responses.
Chronic diabetic wounds do not heal and are often accompanied by infections and poor angiogenesis. We have made a two-layered PVA/CS composite hydrogel MN-CL patch, which has antibacterial, immunoregulatory, and pro-healing properties. The needle tip…
BACKGROUND: ApoB (apolipoprotein B)-containing lipoproteins are causal risk factors for atherosclerotic coronary artery disease (CAD). Since human cathelicidin LL-37 binds to ApoB-100 in this pathological context, we investigated whether the circulat…
Sterile inflammation, resulting from hepatocyte death and subsequent release of damage-associated molecular patterns (DAMPs), significantly contributes to liver disease pathogenesis. Neutrophils, as primary responders to liver injury, undergo NETosis…
Mesenchymal stem cells (MSCs) have emerged as promising alternatives to fight drug-resistant bacterial infections. This study investigates the antibacterial activity of palatal adipose tissue-derived MSCs (PMSCs), particularly when cultured within a…
The gastrointestinal mucus barrier (GIMB) is a gelatinous structure consisting primarily of mucins, water, and cathelicidin. Such a structure is the first line of defense against pathogens in the intestinal cavity and acts an important environment fo…
BACKGROUND: Reinfection in the root canal and periradicular area due to the emergence of antibiotic resistance and/or multidrug-resistant strains of mixed colonization of multispecies periapical endodontic is the main reason for endodontic treatment…
The rise of antimicrobial resistance (AMR) has outpaced the development of new antibiotics, necessitating alternative therapeutic strategies that do not rely on conventional bactericidal approaches. Quorum-sensing (QS), a bacterial communication syst…
OBJECTIVE: This study aimed to elucidate the molecular mechanisms through which CXCL2 contributes to the pathogenesis of idiopathic interstitial pneumonia (IIP). METHODS: Neutrophils were isolated, and the formation of neutrophil extracellular traps…
To identify the differential properties of anti-microbial peptides (AMPs) and proteins in the burying beetle Nicrophorus quadripunctatus and the short sexton beetle Necrodes littoralis, we performed comparative transcriptomic analyses, quantified gen…
PURPOSE: This study aimed to examine the acute effects of continuous and interval cycling on salivary secretory immunoglobulin A (SIgA) and anti-microbial peptides. METHODS: In a randomized crossover trial, 12 healthy young untrained men (22 ± 1 year…
Immune cell populations are dysregulated in COVID-19 for currently unknown reasons: Plasmacytoid dendritic cell (pDC) populations are reduced, thus hampering antiviral responses. CD8T cell populations are reduced, the level of which has emerged as an…
BACKGROUND: Pseudomonas aeruginosa is a major cause of acute nosocomial infections, as well as chronic respiratory infections associated with cystic fibrosis (CF). In chronic lung infections, P. aeruginosa populations typically exhibit extensive phen…
: Bacterial biofilms formed bypose a significant challenge in veterinary medicine due to their intrinsic resistance to antibiotics. Antimicrobial peptides (AMPs) represent a promising alternative. AMPs exert their bactericidal activity by binding to…
OBJECTIVES: The increasing prevalence of antibiotic-resistant Salmonella Typhimurium has highlighted the urgent need for alternative therapeutic strategies. This study engineered a lytic S. Typhimurium bacteriophage to present the antimicrobial pepti…
1. This study investigated whether resveratrol (RES) can regulate the expression of duck cathelicidins (dCATHs) in heterophilic granulocytes (HGs). To address this, HG was isolated from ducks and treated with RES, followed by transcriptome sequencing…
[This corrects the article DOI: 10.3389/froh.2025.1694969.].
This study presents a comprehensive multidimensional assessment of the safety and functional efficacy of Limosilactobacillus fermentum LF61, a strain isolated from human milk. Genomic analysis revealed no virulence factors (VFDB), drug resistance gen…
BACKGROUND: The growing threat of bacterial drug resistance compels researchers to pursue new therapeutic strategies. Finegoldia magna secretes SufA, a subtilisin- like protease that plays a critical role in virulence by degrading host defense molecu…
Viral infectious diseases rank among the leading causes of mortality globally. The rise of drug resistance mechanisms puts the effectiveness of all existing antimicrobial drugs at risk, several of which have become ineffective. Consequently, there is…
Bacterial extracellular vesicles (BEVs) serve as efficient drug-delivery vehicles for bioactive molecules including antimicrobial peptides (AMPs). In the present study, human cathelicidin-derived AMP LL37 was encapsulated in Streptococcus parauberis-…