The only human cathelicidin antimicrobial peptide, playing key roles in innate immune defense, wound healing, and modulation of inflammatory responses.
INTRODUCTION: One of the main causes of infectious disease-related deaths globally is Mycobacterium tuberculosis (M.tb), the causative agent of tuberculosis (TB). Novel treatment strategies are now much more urgent due to the emergence of Extensively…
BACKGROUND: Pseudomonas aeruginosa is a major cause of acute nosocomial infections, as well as chronic respiratory infections associated with cystic fibrosis (CF). In chronic lung infections, P. aeruginosa populations typically exhibit extensive phen…
The gastrointestinal tract hosts a diverse microbial community, named the intestinal microbiota, which plays a vital role in gut health. Host defense peptides (HDPs), such as defensins, help regulate interactions between the host and its microbiota.…
The emergence of drug resistance and host toxicity is associated with conventional antiprotozoal therapies which necessitates development of novel and selective antiparasitic agents. In the present study, novel hybrid peptide which is HP-AP-1 (KRIVQR…
INTRODUCTION: Antimicrobial resistance in bacterial and fungal pathogens poses a major threat to global health, withrecently classified by the WHO as a critical priority pathogen. Antimicrobial peptides (AMPs) have emerged as promising candidates due…
BACKGROUND: The evidence of a low-biomass microbial community in the amniotic fluid (AF) is challenging the traditional concept of a sterile womb. To clarify microbial presence and host responses, a comprehensive, multi-methodological approach is req…
BACKGROUND: Recurrent urinary tract infection (rUTI) is a major diagnostic and management challenge. Dysregulated innate immune responses, including antimicrobial peptides and cytokines, may underlie UTI susceptibility. This study investigates whethe…
BACKGROUND: Dysbiotic oral biofilms produce virulence factors, such as lipopolysaccharide (LPS), triggering and sustaining chronic inflammation in periodontal tissues. Modulation of the bioactivity of these products offers a potential novel, adjuncti…
BACKGROUND: During the COVID-19 pandemic, it became evident that an infection with SARS-CoV-2 is associated with an increased predisposition for thrombembolic events. Recent studies suggest an excessive neutrophil extracellular trap (NET)-formation i…
Due to the complex and variable microenvironment of wounds, bleeding and persistent infections have always posed significant challenges in wound treatment. Designing and developing therapeutic solutions with rapid hemostatic capabilities and antibact…
The human cathelicidin host defense peptide LL-37 forms complexes with nucleic acids that can have either beneficial or detrimental health effects. We suggest that these differential impacts are directly connected to dsDNA binding by LL-37 and to com…
Herpes simplex virus type 1 (HSV-1) is a widespread infectious virus that poses a substantial public health burden. With no specific curative therapy available and current antivirals providing only symptomatic relief, the development of new effective…
The appearance of antibiotic-resistant strains of() is leading to a decreased eradication rate ofinfection. There is an urgent need to find new agents with antimicrobial mechanisms different from those of antibiotics, with therapeutic potential to cl…
While probiotics are increasingly consumed for health benefits, comprehensive safety assessments, particularly for novel strains, are imperative. This study aimed to conduct a holistic safety and efficacy assessment of Bifidobacterium longum subsp. i…
Cathelicidins are crucial antimicrobial peptides (AMPs) that play a key role in the innate immunity of marine vertebrates. The pygmy sperm whale (Kogia breviceps), which resides in environments populated by diverse microbial communities, faces comple…
There is an urgent need for new antimicrobial agents to address the emerging antimicrobial resistance and the lack of novel antibiotics on the market. Antimicrobial peptides (AMPs) have gained significant interest as potential antibiotics over the pa…
BACKGROUND: Alterations of epithelial barrier integrity and immune response play a key role in the pathogenesis of allergic diseases and represent promising targets for nutritional interventions. Selected postbiotics and plant-derived compounds have…
BACKGROUND: To investigate key genes and immune microenvironment dynamics in cervical cancer progression and radiochemotherapy (RCT), focusing on cathelicidin antimicrobial peptide (CAMP)-mediated neutrophil regulation. METHODS: Integrated transcript…
Cancer cell migration is a key step in the metastatic cascade. Understanding its mechanisms represents one of the greatest challenges in modern oncology. Both in vitro and in vivo experimental models and mathematical descriptions of movement dynamics…