The only human cathelicidin antimicrobial peptide, playing key roles in innate immune defense, wound healing, and modulation of inflammatory responses.
Multidrug-resistant Gram-negative pathogens pose a major global medical challenge due to the lack of new antibiotics. Outer membrane vesicles (OMVs) in Gram-negative bacteria significantly contribute to their resistance to antimicrobial peptides (AMP…
This study presents a comprehensive multidimensional assessment of the safety and functional efficacy of Limosilactobacillus fermentum LF61, a strain isolated from human milk. Genomic analysis revealed no virulence factors (VFDB), drug resistance gen…
The growing global threat of antimicrobial resistance (AMR), particularly in cutaneous wound infections, represents a significant clinical and economic challenge. Biofilm formation by multidrug-resistant pathogens, such as, often complicates healing…
Owing to emerging global threats such as viral pandemics and the rise of antibiotic resistance, there is an urgent need for novel approaches to combat drug-resistant pathogens. Antimicrobial peptides (AMPs), also known as cationic host defense peptid…
Transient receptor potential vanilloid 4 (TRPV4) is a polymodal cation channel that is widely expressed in sensory neurons, immune cells, and structural tissues, where it integrates mechanical, osmotic, and chemical stimuli to regulate both physiolog…
INTRODUCTION: Antimicrobial peptides (AMPs) are essential components of the innate immune system, exhibiting diverse mechanisms of action. OBJECTIVE: This study investigates the roles of cathelicidin (LL-37), alpha-defensins, and the S100 proteins S1…
The pathogenicity of Group A Streptococcus (GAS) is tightly regulated by the CovRS two-component system; however, the nature of the direct interaction between CovR and CovS, and how host signals modulate this system, remain poorly understood. Using s…
BACKGROUND: ApoB (apolipoprotein B)-containing lipoproteins are causal risk factors for atherosclerotic coronary artery disease (CAD). Since human cathelicidin LL-37 binds to ApoB-100 in this pathological context, we investigated whether the circulat…
The fever response is triggered during infection and inflammation, but the importance of this response for the function of antimicrobial peptides (AMPs) remains unknown. We discovered that the activity of the human AMP LL-37 is temperature-dependent…
Human cathelicidin peptide LL-37 is encoded by the CAMP gene and plays a key role in innate immunity. It maintains intestinal homeostasis through antibacterial, immunomodulation, and tissue repair functions. This paper reviews the multiple functions…
INTRODUCTION: Elevated levels of serum Vitamin D (VitD) and increased expression of its receptor on peripheral blood cells have been reported in individuals who have been exposed to HIV-1 yet remain seronegative (HESN). This study aimed to investigat…
The host-defense peptide cathelicidin LL37 is an innate immune defense peptide with broad-spectrum antimicrobial effects. Experiments showed that the antimicrobial activity of LL37(17-29), the active core of LL37, was associated with peptide aggregat…
The increasing prevalence of multidrug-resistant (MDR) bacterial infections poses global health challenges, highlighting the urgent need for new antimicrobial agents. The key advantages of antimicrobial peptides are their ability to rapid bactericida…
Rosacea is a chronic inflammatory skin condition marked by excessive M1 macrophage polarization and angiogenesis, resulting in erythema and tissue inflammation. Despite available treatments, many patients experience recurrent flare-ups. This study ex…
The escalating global threat of antimicrobial resistance (AMR) and chronic biofilm-associated infections underscores the urgent need for novel therapeutic agents. Antimicrobial peptides (AMPs) offer a promising alternative due to their potent activit…
BACKGROUND AND AIMS: Nonsteroidal anti-inflammatory drugs (NSAIDs) can cause small intestinal injury and dysbiosis. Although NSAID-induced dysbiosis is well-characterized and contributes to enteropathy, the changes in host-bacterial interactions duri…
Mastitis is a major cause of economic losses in dairy production; however, its prevention and treatment remain challenging. Under field conditions, antimicrobial drugs are frequently administered when somatic cell counts (SCCs) are elevated and signs…
Mesenchymal stem cells (MSCs) have emerged as promising alternatives to fight drug-resistant bacterial infections. This study investigates the antibacterial activity of palatal adipose tissue-derived MSCs (PMSCs), particularly when cultured within a…
AIMS: This study examines the in vitro antibacterial activity of palatal adipose tissue-derived mesenchymal stem cells (PAT-MSCs) and the expression of antimicrobial peptide LL-37, with a particular focus on the effect of three-dimensional (3D) nanof…
BACKGROUND: Antimicrobial peptides are integral components of the innate immune system and play a vital role in maintaining oral homeostasis. LL-37, the only human cathelicidin antimicrobial peptide, has gained increasing attention due to its broad-s…