A synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from epithalamin, studied for its telomerase-activating, anti-aging, and pineal gland regulatory properties.
Various epiphyseal neuropeptides, participating in regulation of the secretory processes, are capable of inducing systemic changes. This circumstance determines both pharmacological and therapeutic properties. The drug elitalamine, representing a pol…
Treatment of diabetic retinopathy remains a most important problem of modern ophthalmology. Bioregulatory therapy has been widely used in recent years as one of promising trends in clinical medicine. The purpose of this study was to evaluate the effi…
OBJECTIVES: The review on our own data on the effect of the pineal peptide preparation Epithalamin on free radical processes in rodents and humans is presented in this paper. RESULTS: The activity of Cu, Zn-superoxide dismutase (SOD) was found decrea…
Fifty female CBA mice were injected s.c. either with 0.1 ml saline, or with synthetic thymic dipeptide Lys-Glu or with synthetic pineal tetrapeptide Ala-Glu-Asp-Gly both in a single dose of 0.1 microg/animal monthly for five consecutive days from the…
Endocrine cells in the stomach of pinealectomized rats after injection of epithalone (pineal gland peptide) were studied by immunohistochemical tests, morphometry, and image analysis microscopic images. A functional relationship was found between the…
Some natural peptides, referred to as cytomedines, were isolated from different organs: cortexin and epithalamin (both from the brain), cordialin (heart), hepalin (liver) and thymalin (thymus),--to test their stimulating effects on the growth in orga…
The effect of epithalone on the age-specific time course of lipid peroxidation was studied in inadaptive Drosophila melanogaster strains. A single dose of epithalone at the larval stage decreased the level of conjugated hydroperoxides and Schiff base…
The effects of cortexin, epithalamin, and synthetic peptides on the growth of processes in sensory neurons and on the development of fragments of cortical and subcortical brain structures were studied in organotypic cultures from 10-11-day chick embr…
Effects of synthetic pineal tetrapeptide L-Ala-L-Glu-L-Asp-L-Glu (Epithalon) on specific catalase activity and the content of conjugated hydroperoxides in highly inbred Drosophila melanogaster lines differing in reproductive functions were studied. I…
The geroprotector activity of epitalon, a synthetic tetrapeptide Ala-Glu-Asp-Gly, was studied on the Drosophila melanogaster wild strain Canton-S. The substance was added to the culture medium only at the developmental stage (from egg to larva). Epit…
The effects of peptide bioregulators epithalon and vilon on the dynamics of irradiation-induced apoptotic death of spleen lymphocytes in rats indicate that these agents inhibit physiologically programmed cell death. The antiapoptotic effect of vilon…
The influence of co-administration of alpha-methyl-p-tyrosine (inhibitor of catecholamine synthesis) and alpha-(+) beta-adrenergic antagonists under conditions of acute hypobaric hypoxia or pretreatment with epithalamin on cyclic nucleotide content i…
The data on a randomized treatment of 100 patients with locally advanced cervical carcinoma are discussed. Half of the patients received complex therapy while the rest--radiation alone (control). The modality also included immunotherapy with epithala…
The effects of a single-shot intraperitoneally administration of melatonin in a dose of 1 mg per kg body weight and epithalamin in a dose of 2.5 mg per kg body weight on the activities of Na+, K(+)-ATPase and 5'-nucleotidase were investigated in the…
Natural brain peptides cortexin and epithalamine, and synthetic polypeptides were used to study their effects on organotypic culture of dorsal root ganglia and brain tissue from a 10-11-day old chick embryo. The effects involved activation of the tis…
Epithelamine made in Russia (Samson, St. Petersburg) was tried for effects on carbohydrate metabolism and cardiovascular system in 33 patients with non-insulin-dependent diabetes mellitus (NIDDM). Adjuvant use of epithelamine in combined treatment of…
Treatment with pineal peptide preparation epithalamin was followed by the increase of the mean lifespan of female D. melanogaster, SHR mice, C3H/Sn mice and LIO rats by 11-31% (P < 0.05). Ninety percent mortality as well as maximum lifespan were incr…