A synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from epithalamin, studied for its telomerase-activating, anti-aging, and pineal gland regulatory properties.
5-day morning injections to pubertal male rats of polypeptide epithalamin preparation obtained from cattle epiphysis, in dose of 0.25 mg/100 g body mass induced the increase of serotonin epiphyseal concentration night peak, N-acetylserotonin and mela…
Chronic administration of pineal peptide drug epitalamin (0.5 mg/kg for 5 to 10 days) modulated the rat circadian locomotor activity: the animals with low circadian rhythm amplitude were activated whereas the rats with an obvious circadian fluctuatio…
After chronic administration of epithalamin (a pineal peptide drug), an increase in the amplitude and shifts in the acrophase of rat's circadian locomotor activity to late hours were observed. These results were obtained only in rats with low initial…
The study was concerned with the influence of postnatal treatment with antioxidant tocopherol, antidiabetic drug phenformin and low-molecular polypeptide factors of the thymus (thymalin) and pineal gland (epithalamin) on transplacental carcinogenicit…
The effect of thymalin and epithalamin on dissemination of tumors treated by pulsed laser radiation was studied in C57B1 female mice bearing subcutaneously transplanted melanoma B16 and Lewis carcinoma. Radiation was delivered from TOC-1001 neodymium…
The experiments on rats have shown changes in the learning ability of animals. The learning of locomotor reactions of escape and avoidance conditioned reflex was accelerated in animals after pinealectomy. Training of rats in U-shaped and 16-door maze…
Altogether 78 patients with dysovarian cardiomyopathy were examined, of them in 19 patients the FSH, LH, prolactin, estradiol and testosterone levels were studied. Function of the epiphysis was evaluated by melatonin excretion with urine in 46 patien…
Synergism between parathyroidin and epithalamin (an extract from the cattle epiphyses) with relation to phosphorus metabolism was revealed in experiments on guinea-pigs. Both drugs possessed a hypophosphatemic effect. The influence of epithalamin on…
The postnatal action of low-molecular polypeptide factors of thymus (FT), pineal gland (FP), bone marrow (FRM) and anterior hypothalamus (FAH) on transplacental carcinogenic effect of N-nitroso-N-ethylurea in rats was studied. Both FT and FP administ…
The influence of epithalamine on the blood content of immunoreactive follicle-stimulating and luteinizing hormones and prolactin was studied in 49 persons of both sexes and albino rats. It was shown that epithalamine promotes an increase in the conce…
Three-month-old female rats were exposed to a single x-ray irradiation (400 rad). Beginning from week 3 after irradiation the animals were treated with 0.2 mg of thymic factor (thymarin) or pineal factor (epithalamine) dissolved in 0.2 ml of normal s…
The authors report the results of experimental and clinical estimation of the effect of polypeptide extract of the epiphysis (epithalamin) on cervical cancer. Injection of epithalamin is shown to improve the cell immunity indices and renders an antit…
Daily treatment of hemicastrated young rats with 0.57 mug of stilbestrol inhibited compensatory ovarian hypertrophy (COH) by 48% in the 3-month animals and by 3% only in the 18-month animals. Administration of L-DOPA, dilantin, epithalamin or phenofo…