Doklady Akademii nauk|1997|Anisimov V et al.|2 citations
PMID: 9147629
A synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from epithalamin, studied for its telomerase-activating, anti-aging, and pineal gland regulatory properties.
The effect of cortexin and epithalamin on the cell growth rate was investigated in the organotypic tissue culture of dorsal root ganglia (DRG), and of cortex and subcortical structures of 10-11-day old chick embryos. Cortexin in concentrations of 20…
It was shown previously that epithalamin delays age-related changes in reproductive and immune systems and increases the life span of mice and rats. These effects could be mediated by stimulating influences of epithalamin on synthesis and secretion o…
An epigenetic approach starts out from the direct (rather than the underlying genetic) causes. An epigenetic approach to aging has little chance of succeeding before a minimum amount of knowledge has been accumulated on the "genetic programming" that…
Endocrine function of thymus estimated by titer of thymic serum factor is inhibited in pubertal mice CBA/Ca under conditions of pharmacological inhibition of epiphysis function by beta-adrenoblocking agent anapriline. After blinding and epithalamine…
To further define the role played by protein kinase C (PKC) in the activation of the neutrophil NADPH oxidase, we have utilized a pseudosubstrate of PKC which was myristoylated at the N terminus. In electropermeabilized neutrophils, the myristoylated…
Effects of pineal peptides on the accumulation of cyclic nucleotides of the human thyroid and its secretory activity were analysed on the basis of the data obtained after operation from patients with nodular euthyroid goiter) incubated with Epithalam…
Reaction of the human TSH-sensitive and TSH-refractory thyroid, obtained from patients with hyperthyroidism, on pineal peptides was studied in vitro. It was shown, that pineal peptides (Epythalamine) are inhibitors of cAMP accumulation and hormone re…
The biosynthesis of serotonin into melatonin was decreased in old (18-20-month) in comparison to young (4-5-month) male Wistar rats. 5-day morning injections to young and old rats with polypeptide pineal preparation (epithalamin) in a dose of 2.5 mg/…
A peptide preparation of the pineal, epithalamin, when administered chronically, exerts a modulating influence on the diurnal fluctuations of the motoric activity of rats. It also decreases the amplitude of apomorphine stereotypy and induces a restru…
On the pinealectomized rats shifts of main parameters of forced swimming and its time course with increase of rhythmical depression index were observed. Pinealectomy also potentiated depressogenic effect of reserpine which was attenuated by melatonin…