Studies

Synthesis, biological activity and conformational analysis of cyclic GRF analogs.

International journal of peptide and protein research|1988|Felix A et al.

A novel cyclic GRF analog, cyclo(Asp8-Lys12)-[Asp8,Ala15]-GRF(1-29)-NH2, i.e. cyclo8,12[Asp8,Ala15]-GRF(1-29)-NH2, was synthesized by the solid phase procedure and found to retain significant biological activity. Solid phase cyclization of Asp8 to Ly…

Animal StudySermorelin

PMID: 3149952

Sequence of peptides from Saccharomyces cerevisiae glutamine synthetase. N-terminal peptide and ATP-binding domain.

The Journal of biological chemistry|1988|Kim K, Rhee S

Sequences of seven tryptic peptides derived from Saccharomyces cerevisiae glutamine synthetase have been determined. The amino terminus of yeast enzyme is acetylated and has the following sequence: acetyl-Ala-Glu-Ala-Ser-Ile-Glu-Lys. Neither higher e…

Synthetic peptide analogs to barnacle settlement pheromone.

Peptides|1988|Tegtmeyer K, Rittschof D

Barnacle pheromone enhances the rate of settlement and metamorphosis of larvae of Balanus amphitrite Darwin. Analogs to the heterogenous pheromone peptides were sought. Settlement assays were used to assess both the pheromone and the potential analog…

GHK-Cu

PMID: 3247257

Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+.

FEBS letters|1988|Maquart F et al.

Glycyl-L-histidyl-L-lysine (GHK) is a tripeptide with affinity for copper(II) ions and was isolated from human plasma. This peptide appears to play a physiological role in wound healing. We report the stimulating effect of GHK-Cu on collagen synthesi…

GHK-Cu

PMID: 3169264

Transient vs. steady end-systolic pressure-volume relation in dog left ventricle.

The American journal of physiology|1987|Igarashi Y et al.

We compared transient slope of end-systolic pressure-volume line (T-Emax) with steady Emax (S-Emax) in isolated cross-circulated canine left ventricles. T-Emax is the slope of the end-systolic pressure-volume line (ESPVL) determined from the last ste…

Animal StudySemax

PMID: 3578548

Effect of two thymosin fraction 5 polypeptides on human peripheral blood lymphocytes.

Immunopharmacology and immunotoxicology|1987|Kokkinopoulos D et al.

Thymosin fraction 5 polypeptides beta 4 and alpha 1 were tested for their ability to affect certain immunological parameters of human peripheral blood lymphocytes (PBL). PBL were cultured with various concentrations of the peptides for 24 hours. Thym…

TB-500

PMID: 2893819

Enzyme immunoassay measurement of thymosin beta 4.

Journal of immunoassay|1987|Weller F, Mutchnick M

An enzyme immunoassay for the measurement of thymosin beta 4, a chemically characterized thymic polypeptide, is described. A limited amount of reagent antiserum to synthetic thymosin beta 4 is incubated with liquid-phase thymosin beta 4. Unbound anti…

TB-500

PMID: 3305577

Immunoregulatory effects of fraction 5 thymus peptides. I. Thymosin alpha 1 enhances while thymosin beta 4 suppresses the human autologous and allogeneic mixed lymphocyte reaction.

Immunopharmacology|1987|Baxevanis C et al.

Thymosin alpha 1 and thymosin beta 4, two peptides isolated from preparations of calf thymus fraction 5, were tested in the human mixed lymphocyte reaction (MLR). Thymosin alpha 1 was found capable of enhancing both the allogeneic and autologous MLR.…

In VitroTB-500

PMID: 2954929

On the molecular size of thymosins.

FEBS letters|1987|Haritos A et al.

The immunoregulatory polypeptide prothymosin alpha and its biologically active N-terminal fragment thymosin alpha 1m, with relative molecular masses of 12,500 and 3108 respectively, were found to behave as oligomers (trimers to hexamers) in gel-filtr…

TB-500

PMID: 3595856

Determination of thymosin beta 4 in human blood cells and serum.

Journal of chromatography|1987|Hannappel E, van Kampen M

A simple one-step procedure for the determination of thymosin beta 4 in whole blood, various blood corpuscles, plasma and serum by reversed-phase high-performance liquid chromatography (HPLC) is described. The blood cells were isolated by a Ficoll de…

TB-500

PMID: 3654821

Molecular cloning of the cDNA for rat spleen thymosin beta 10 and the deduced amino acid sequence.

Archives of biochemistry and biophysics|1987|Goodall G, Horecker B

A rat spleen cDNA library was prepared and employed for the molecular cloning of the cDNA for thymosin beta 10, a peptide that previously had been found to accompany the closely related peptide, thymosin beta 4, in several species of mammals (S. Eric…

Animal StudyTB-500

PMID: 3606131

Identification and characterization of mRNAs regulated by nerve growth factor in PC12 cells.

Molecular and cellular biology|1987|Leonard D, Ziff E, Greene L

Differential screening of cDNA libraries was used to detect and prepare probes for mRNAs that are regulated in PC12 rat pheochromocytoma cells by long-term (2-week) treatment with nerve growth factor (NGF). In response to NGF, PC12 cells change from…

Animal StudyTB-500

PMID: 3670309

The role of the thymus-hypothalamus-pituitary-gonadal axis in normal immune processes and autoimmunity.

The Journal of rheumatology|1987|Golsteyn E, Fritzler M

Gonadal steroids play an important role in the development and regulation of the immune system. Their effects may be mediated through a thymus-hypothalamus-pituitary-gonadal axis. The thymus gland secretes factor(s), including thymosin beta 4, that a…

ReviewTB-500

PMID: 3323509

Differential expression of the human thymosin-beta 4 gene in lymphocytes, macrophages, and granulocytes.

Journal of immunology (Baltimore, Md. : 1950)|1987|Gondo H et al.

A cDNA clone encoding human thymosin-beta 4 was isolated from a cDNA library prepared from peripheral blood leukocytes of a patient with acute lymphocytic leukemia. This clone contained the entire coding sequence of 43 amino acid residues of thymosin…

Animal StudyIn VitroTB-500

PMID: 3500230

[Effect of thymalin and epithalamin on the metastasis of experimental tumors irradiated with pulsed laser radiation].

Voprosy onkologii|1987|Moskalik K

The effect of thymalin and epithalamin on dissemination of tumors treated by pulsed laser radiation was studied in C57B1 female mice bearing subcutaneously transplanted melanoma B16 and Lewis carcinoma. Radiation was delivered from TOC-1001 neodymium…

Animal StudyEpitalon

PMID: 3811311

[Changes in the learning ability of epiphysectomized rats].

Biulleten' eksperimental'noi biologii i meditsiny|1987|Belozertsev I, Tertyshnik I

The experiments on rats have shown changes in the learning ability of animals. The learning of locomotor reactions of escape and avoidance conditioned reflex was accelerated in animals after pinealectomy. Training of rats in U-shaped and 16-door maze…

Animal StudyEpitalon

PMID: 3676467

Synergism and diurnal variations of human growth hormone-releasing factor (1-29)NH2 and thyrotropin-releasing factor on growth hormone release in dairy calves.

Domestic animal endocrinology|1987|Lapierre H et al.

Sixteen male Holstein calves averaging 168 kg body weight (BW) were used to determine the effects of human growth hormone-releasing factor (1-29)NH2 (hGRF (1-29)NH2; .22 micrograms/kg BW), thyrotropin-releasing factor (TRF; .165 micrograms/kg BW) or…

Sermorelin

PMID: 2907311

Influence of age and sex on basal secretion of growth hormone (GH) and on GH-induced release by porcine GH-releasing factor pGRF(1-29NH2) in growing pigs.

Domestic animal endocrinology|1987|Dubreuil P et al.

The aim of this study was to determine the effect of age and sex on basal secretory patterns of growth hormone (GH) and growth hormone-releasing factor (GRF) induced GH release. Eighteen pigs (9 castrated males and 9 females) were stimulated with pGR…

Animal StudySermorelin

PMID: 2907313

Growth hormone and prolactin secretion after growth hormone-releasing hormone administration, in anorexia nervosa patients, normal controls and tamoxifen-pretreated volunteers.

Clinical endocrinology|1987|Casanueva F et al.

Anorexia nervosa is associated with several abnormalities in GH secretion elicited by different stimuli. To investigate the precise mechanism of this alteration, GHRH was administered to 14 women: a group of eight anorexia nervosa patients in the acu…

Randomized Controlled TrialSermorelin

PMID: 2897260

Synthesis, biological activity and conformational analysis of cyclic GRF analogs.

Sequence of peptides from Saccharomyces cerevisiae glutamine synthetase. N-terminal peptide and ATP-binding domain.

Synthetic peptide analogs to barnacle settlement pheromone.

Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+.

Transient vs. steady end-systolic pressure-volume relation in dog left ventricle.

Effect of two thymosin fraction 5 polypeptides on human peripheral blood lymphocytes.

Enzyme immunoassay measurement of thymosin beta 4.

Immunoregulatory effects of fraction 5 thymus peptides. I. Thymosin alpha 1 enhances while thymosin beta 4 suppresses the human autologous and allogeneic mixed lymphocyte reaction.

On the molecular size of thymosins.

Determination of thymosin beta 4 in human blood cells and serum.

Molecular cloning of the cDNA for rat spleen thymosin beta 10 and the deduced amino acid sequence.

Synthesis of calf thymosin beta 4 fragment 16-38 and its effect on the impaired blastogenic response of T-lymphocytes of a uremic patient with pneumonia.

Identification and characterization of mRNAs regulated by nerve growth factor in PC12 cells.

The role of the thymus-hypothalamus-pituitary-gonadal axis in normal immune processes and autoimmunity.

Differential expression of the human thymosin-beta 4 gene in lymphocytes, macrophages, and granulocytes.

[Effect of thymalin and epithalamin on the metastasis of experimental tumors irradiated with pulsed laser radiation].

[Changes in the learning ability of epiphysectomized rats].

Synergism and diurnal variations of human growth hormone-releasing factor (1-29)NH2 and thyrotropin-releasing factor on growth hormone release in dairy calves.

Influence of age and sex on basal secretion of growth hormone (GH) and on GH-induced release by porcine GH-releasing factor pGRF(1-29NH2) in growing pigs.

Growth hormone and prolactin secretion after growth hormone-releasing hormone administration, in anorexia nervosa patients, normal controls and tamoxifen-pretreated volunteers.