Studies | Pepdox

Depot Medroxyprogesterone Acetate Use Is Associated With Elevated Innate Immune Effector Molecules in Cervicovaginal Secretions of HIV-1-Uninfected Women.

Journal of acquired immune deficiency syndromes (1999)|2015|Guthrie B et al.|24 citations

OBJECTIVE: The effects of sex hormones on the immune defenses of the female genital mucosa and its susceptibility to infections are poorly understood. The injectable hormonal contraceptive depot medroxyprogesterone acetate (DMPA) may increase the ris…

Animal StudyLL-37

PMID: 25622059

Elucidation of the RamA regulon in Klebsiella pneumoniae reveals a role in LPS regulation.

PLoS pathogens|2015|De Majumdar S et al.|109 citations

Klebsiella pneumoniae is a significant human pathogen, in part due to high rates of multidrug resistance. RamA is an intrinsic regulator in K. pneumoniae established to be important for the bacterial response to antimicrobial challenge; however, litt…

ZL-2, a cathelicidin-derived antimicrobial peptide, has a broad antimicrobial activity against gram-positive bacteria and gram-negative bacteria in vitro and in vivo.

Archives of pharmacal research|2015|Tu J et al.|7 citations

Alloferons are a group of naturally occurring peptides primarily isolated from insects that are capable of stimulating mouse and human NK cell cytotoxicity toward cancer cells. In this study, we found that a modified antibacterial peptide had a broad…

Animal StudyIn VitroLL-37

PMID: 25636224

Using anti-biofilm peptides to treat antibiotic-resistant bacterial infections.

Postdoc journal : a journal of postdoctoral research and postdoctoral affairs|2015|de la Fuente-Núñez C, Hancock R|14 citations

Host defense (antimicrobial) peptides (HDPs) are produced by virtually all organisms and have an important role in protection against microbial infections. Some naturally occurring peptides such as the human cathelicidin LL-37 and the bovine peptide…

LL-37

PMID: 27563687

The innate defense antimicrobial peptides hBD3 and RNase7 are induced in human umbilical vein endothelial cells by classical inflammatory cytokines but not Th17 cytokines.

Microbes and infection|2015|Burgey C et al.|19 citations

Antimicrobial peptides are multifunctional effector molecules of innate immunity. In this study we investigated whether endothelial cells actively contribute to innate defense mechanisms by expression of antimicrobial peptides. We therefore stimulate…

In VitroLL-37

PMID: 25637949

Antimicrobial peptide Cathelicidin-BF prevents intestinal barrier dysfunction in a mouse model of endotoxemia.

International immunopharmacology|2015|Song D et al.|49 citations

Intestinal barrier functions are altered during the development of sepsis. Cathelicidin antimicrobial peptides, such as LL-37 and mCRAMP, can protect animals against intestinal barrier dysfunction. Cathelicidin-BF (C-BF), a new cathelicidin peptide p…

Animal StudyLL-37

PMID: 25639228

The impact of vitamin D on the innate immune response to uropathogenic Escherichia coli during pregnancy.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases|2015|Ramos N et al.|17 citations

Urinary tract infections are highly common during pregnancy, and can cause serious complications for the mother and baby. Vitamin D, predominantly obtained from the sunlight, is known to have an effect on the urothelium, with immunomodulatory capacit…

In VitroLL-37

PMID: 25640157

Antimicrobial protein and Peptide concentrations and activity in human breast milk consumed by preterm infants at risk of late-onset neonatal sepsis.

PloS one|2015|Trend S et al.|59 citations

OBJECTIVE: We investigated the levels and antimicrobial activity of antimicrobial proteins and peptides (AMPs) in breast milk consumed by preterm infants, and whether deficiencies of these factors were associated with late-onset neonatal sepsis (LOS)…

LL-37

PMID: 25643281

The antimicrobial peptide cathelicidin-BF could be a potential therapeutic for Salmonella typhimurium infection.

Microbiological research|2015|Xia X, Zhang L, Wang Y|35 citations

Resistance is increasing to several critical antimicrobials used to treat Salmonella typhimurium infection, urging people to search for new antimicrobial agents. In this work, we reported the possibility of a potent antimicrobial peptide cathelicidin…

Animal StudyLL-37

PMID: 25644952

Antimicrobial peptide LL-37 promotes antigen-specific immune responses in mice by enhancing Th17-skewed mucosal and systemic immunities.

European journal of immunology|2015|Kim S et al.|27 citations

The human antimicrobial peptide LL-37 is known to have chemotactic and modulatory activities on various cells including monocytes, T cells, and epithelial cells. Given that LL-37 enhances chemotactic attraction and modulates the activity of DCs, it i…

Animal StudyLL-37

PMID: 25655317

Evaluation of antimicrobial peptides and cytokine production in primary keratinocyte cell culture from healthy and atopic beagles.

Experimental dermatology|2015|Santoro D et al.|22 citations

Increased secretion of antimicrobial peptides and cytokines is present in atopic skin. The purpose of this study was to compare the production of β-defensin (cBD)3-like, cathelicidin (cCath) and cytokines in atopic and healthy canine keratinocytes. S…

Animal StudyIn VitroLL-37

PMID: 25660992

Analysis of mixed biofilm (Staphylococcus aureus and Pseudomonas aeruginosa) by laser ablation electrospray ionization mass spectrometry.

Biofouling|2015|Dean S et al.|24 citations

Pseudomonas aeruginosa and Staphylococcus aureus are ubiquitous pathogens often found together in polymicrobial, biofilm-associated infections. This study is the first to use laser ablation electrospray ionization mass spectrometry (LAESI-MS) to rapi…

LL-37

PMID: 25672229

Antimicrobial peptide FF/CAP18 induces apoptotic cell death in HCT116 colon cancer cells via changes in the metabolic profile.

International journal of oncology|2015|Kuroda K et al.|41 citations

Metabolic reprogramming is one of the hallmarks of cancer and can be targeted by therapeutic agents. We previously reported that cathelicidin-related or modified antimicrobial peptides, such as FF/CAP18, have antiproliferative effects on the squamous…

In VitroLL-37

PMID: 25672949

Vitamin D Status and Its Association with the SCORAD Score and Serum LL-37 Level in Korean Adults and Children with Atopic Dermatitis.

Annals of dermatology|2015|Han T et al.|21 citations

BACKGROUND: Vitamin D insufficiency could be associated with the prevalence of atopic dermatitis (AD). OBJECTIVE: To examine vitamin D status and the relations between serum 25-hydroxyvitamin D levels, SCORAD score, serum LL-37 level, and body mass i…

LL-37

PMID: 25673925

In Vivo Role of TLR2 and MyD88 Signaling in Eliciting Innate Immune Responses in Staphylococcal Endophthalmitis.

Investigative ophthalmology & visual science|2015|Talreja D, Singh P, Kumar A|49 citations

PURPOSE: The purpose of this study was to investigate the protective mechanisms evoked by TLR2 and MyD88 signaling in bacterial endophthalmitis in vivo. METHODS: Endophthalmitis was induced in wild-type (WT), TLR2(-/-), MyD88(-/-), and Cnlp(-/-) mice…

Animal StudyLL-37

PMID: 25678692

Modulating the internalization of bacille Calmette-Guérin by cathelicidin in bladder cancer cells.

Urology|2015|Choi S et al.|10 citations

OBJECTIVE: To confirm the role of cathelicidin (LL-37) in the internalization of bacille Calmette-Guérin (BCG) into bladder cancer cells. METHODS: Enzyme-linked immunosorbent assay and reverse transcription polymerase chain reaction analysis evaluate…

LL-37

PMID: 25681250

Human antimicrobial peptide LL-37 induces glial-mediated neuroinflammation.

Biochemical pharmacology|2015|Lee M et al.|50 citations

LL-37 is the sole cathelicidin-derived antimicrobial peptide found in humans. It becomes active upon C-terminal cleavage of its inactive precursor hCAP18. In addition to antimicrobial action, it also functions as an innate immune system stimulant in…

LL-37

PMID: 25686659

Do antimicrobial peptides and complement collaborate in the intestinal mucosa?

Frontiers in immunology|2015|Kopp Z et al.|48 citations

It is well understood that multiple antimicrobial peptides (AMPs) are constitutively deployed by the epithelium to bolster the innate defenses along the entire length of the intestines. In addition to this constitutive/homeostatic production, AMPs ma…

ReviewLL-37

PMID: 25688244

Cationic antimicrobial peptide resistance mechanisms of streptococcal pathogens.

Biochimica et biophysica acta|2015|LaRock C, Nizet V|80 citations

Cationic antimicrobial peptides (CAMPs) are critical front line contributors to host defense against invasive bacterial infection. These immune factors have direct killing activity toward microbes, but many pathogens are able to resist their effects.…

ReviewLL-37

PMID: 25701232

Expression of the ATP-gated P2X7 Receptor on M Cells and Its Modulating Role in the Mucosal Immune Environment.

Immune network|2015|Kim S, Lee H, Jang Y|8 citations

Interactions between microbes and epithelial cells in the gastrointestinal tract are closely associated with regulation of intestinal mucosal immune responses. Recent studies have highlighted the modulation of mucosal immunity by microbe-derived mole…

LL-37

PMID: 25713508