Studies

Mechanisms of Action of Vitamin D as Supplemental Therapy for Pneumocystis Pneumonia.

Antimicrobial agents and chemotherapy|2017|Lei G et al.|49 citations

The combination of trimethoprim and sulfamethoxazole (TMP-SMX) is the most effective regimen for therapy ofpneumonia (PCP). As many patients with PCP are allergic or do not respond to it, efforts have been devoted to develop alternative therapies for…

Animal StudyLL-37

PMID: 28760906

Cathelicidins display conserved direct antiviral activity towards rhinovirus.

Peptides|2017|Sousa F et al.|70 citations

Human rhinoviruses (HRVs) are the most common cause of viral respiratory tract infections, and are associated with significant morbidity and mortality in immunocompromised individuals and patients with pre-existing pulmonary conditions. The therapeut…

Immuno-Stimulatory Peptides as a Potential Adjunct Therapy against Intra-Macrophagic Pathogens.

Molecules (Basel, Switzerland)|2017|Silva T, Gomes M|16 citations

The treatment of infectious diseases is increasingly prone to failure due to the rapid spread of antibiotic-resistant pathogens. Antimicrobial peptides (AMPs) are natural components of the innate immune system of most living organisms. Their capacity…

ReviewLL-37

PMID: 28777342

As-CATH1-6, novel cathelicidins with potent antimicrobial and immunomodulatory properties from, play pivotal roles in host antimicrobial immune responses.

The Biochemical journal|2017|Chen Y et al.|42 citations

Crocodilians are regarded as possessing a powerful immune system. However, the composition and action of the crocodilian immune system have remained unclear until now. Cathelicidins, the principal family of host defense peptides, play pivotal roles i…

Animal StudyLL-37

PMID: 28798159

Identification of the first cathelicidin gene from skin of Chinese giant salamanders Andrias davidianus with its potent antimicrobial activity.

Developmental and comparative immunology|2017|Yang H et al.|23 citations

Cathelicidins, as effector molecules, play important roles against infections and represent a crucial component of the innate immune system in vertebrates. They are widely studied in mammals, but little is known in amphibians. In the present study, w…

LL-37

PMID: 28801228

RocA Is an Accessory Protein to the Virulence-Regulating CovRS Two-Component System in Group A Streptococcus.

Infection and immunity|2017|Jain I et al.|22 citations

Regulating gene expression during infection is critical to the ability of pathogens to circumvent the immune response and cause disease. This is true for the group A(GAS), a pathogen that causes both invasive (e.g., necrotizing fasciitis) and noninva…

LL-37

PMID: 28808155

Carbon Nanoparticles Inhibit the Antimicrobial Activities of the Human Cathelicidin LL-37 through Structural Alteration.

Journal of immunology (Baltimore, Md. : 1950)|2017|Findlay F et al.|20 citations

Host defense peptides, also known as antimicrobial peptides, are key elements of innate host defense. One host defense peptide with well-characterized antimicrobial activity is the human cathelicidin, LL-37. LL-37 has been shown to be upregulated at…

In VitroLL-37

PMID: 28814602

Saliva-Derived Host Defense Peptides Histatin1 and LL-37 Increase Secretion of Antimicrobial Skin and Oral Mucosa Chemokine CCL20 in an IL-1-Independent Manner.

Journal of immunology research|2017|Boink M et al.|17 citations

Even though skin and oral mucosae are continuously in contact with commensal and opportunistic microorganisms, they generally remain healthy and uninflamed. Host defense peptides (HDPs) make up the body's first line of defense against many invading p…

LL-37

PMID: 28815185

In vivo therapeutic efficacy of frog skin-derived peptides against Pseudomonas aeruginosa-induced pulmonary infection.

Scientific reports|2017|Chen C, Mangoni M, Di Y|34 citations

Pseudomonas aeruginosa is an opportunistic and frequently drug-resistant pulmonary pathogen especially in cystic fibrosis sufferers. Recently, the frog skin-derived antimicrobial peptide (AMP) Esc(1-21) and its diastereomer Esc(1-21)-1c were found to…

Animal StudyIn VitroLL-37

PMID: 28819175

Identification of bacterial biofilm and the Staphylococcus aureus derived protease, staphopain, on the skin surface of patients with atopic dermatitis.

Scientific reports|2017|Sonesson A et al.|76 citations

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by an impaired epidermal barrier, dysregulation of innate and adaptive immunity, and a high susceptibility to bacterial colonization and infection. In the present study, bact…

Animal StudyIn VitroLL-37

PMID: 28821865

Vitamin D, Cathelicidin, Prolactin, Autoantibodies, and Cytokines in Different Forms of Pulmonary Tuberculosis versus Sarcoidosis.

The Israel Medical Association journal : IMAJ|2017|Vasilyevna Belyaeva I et al.|9 citations

BACKGROUND: Vitamin D insufficiency is associated with autoimmune and chronic inflammatory diseases such as tuberculosis and sarcoidosis. OBJECTIVES: To evaluate the vitamin D-dependent mechanisms of immunity and autoimmunity in different forms of pu…

LL-37

PMID: 28825769

LL-37 causes cell death of human nasal epithelial cells, which is inhibited with a synthetic glycosaminoglycan.

PloS one|2017|Thomas A et al.|12 citations

LL-37 is an immune peptide that regulates innate and adaptive immune responses in the upper airways. Elevated levels of LL-37 have been linked to cell death and inflammatory diseases, such as chronic rhinosinusitis (CRS). Glycosaminoglycans (GAGs) ar…

Animal StudyLL-37

PMID: 28837619

The Mla pathway is critical for Pseudomonas aeruginosa resistance to outer membrane permeabilization and host innate immune clearance.

Journal of molecular medicine (Berlin, Germany)|2017|Munguia J et al.|33 citations

UNLABELLED: Pseudomonas aeruginosa is an important opportunistic pathogen that has become a serious problem due to increased rates of antibiotic resistance. Due to this along with a dearth in novel antibiotic development, especially against Gram-nega…

Animal StudyLL-37

PMID: 28844103

Histones bundle F-actin filaments and affect actin structure.

PloS one|2017|Blotnick E, Sol A, Muhlrad A|12 citations

Histones are small polycationic proteins complexed with DNA located in the cell nucleus. Upon apoptosis they are secreted from the cells and react with extracellular polyanionic compounds. Actin which is a polyanionic protein, is also secreted from n…

LL-37

PMID: 28846729

Antimicrobial cathelicidin peptide LL‑37 induces NET formation and suppresses the inflammatory response in a mouse septic model.

Molecular medicine reports|2017|Hosoda H et al.|33 citations

LL‑37 is the only known member of the cathelicidin family of antimicrobial peptides in humans. In addition to its broad spectrum of antimicrobial activities, LL‑37 may modulate various inflammatory reactions. The authors previously revealed that LL‑3…

Animal StudyLL-37

PMID: 28849130

Activated Mesenchymal Stem Cells Interact with Antibiotics and Host Innate Immune Responses to Control Chronic Bacterial Infections.

Scientific reports|2017|Johnson V et al.|90 citations

Chronic bacterial infections associated with biofilm formation are often difficult to resolve without extended courses of antibiotic therapy. Mesenchymal stem cells (MSC) exert antibacterial activity in vitro and in acute bacterial infection models,…

Animal StudyIn VitroLL-37

PMID: 28851894

Vitamin D Levels in Premature Children Admitted to the Hospital with Viral Respiratory Infection.

Pediatric allergy, immunology, and pulmonology|2017|Gunville C et al.|1 citation

Children born preterm are at risk of hospital admission for respiratory infection in the first years of life. Vitamin D deficiency has been associated with increased risk of developing lower respiratory tract infection (LRTI). We assessed vitamin D l…

LL-37

PMID: 35923008

Characterization of Two Novel Lipopolysaccharide Phosphoethanolamine Transferases in Pasteurella multocida and Their Role in Resistance to Cathelicidin-2.

Infection and immunity|2017|Harper M et al.|17 citations

The lipopolysaccharide (LPS) produced by the Gram-negative bacterial pathogenhas phosphoethanolamine (PEtn) residues attached to lipid A, 3-deoxy-d-manno-octulosonic acid (Kdo), heptose, and galactose. In this report, we show that PEtn is transferred…

LL-37

PMID: 28874446

MEK inhibition enhances efficacy of bacillus Calmette-Guérin on bladder cancer cells by reducing release of Toll-like receptor 2-activated antimicrobial peptides.

Oncotarget|2017|Whang Y et al.|11 citations

Bacillus Calmette-Guérin (BCG) is one of the standard treatment options for non-muscle-invasive bladder cancer. The details of the biological defense mechanisms against BCG remain unclear. Here, we investigated whether BCG-induced release of antimicr…

LL-37

PMID: 28881802

Mechanisms of Action of Vitamin D as Supplemental Therapy for Pneumocystis Pneumonia.

Cathelicidins display conserved direct antiviral activity towards rhinovirus.

Immuno-Stimulatory Peptides as a Potential Adjunct Therapy against Intra-Macrophagic Pathogens.

As-CATH1-6, novel cathelicidins with potent antimicrobial and immunomodulatory properties from, play pivotal roles in host antimicrobial immune responses.

Identification of the first cathelicidin gene from skin of Chinese giant salamanders Andrias davidianus with its potent antimicrobial activity.

RocA Is an Accessory Protein to the Virulence-Regulating CovRS Two-Component System in Group A Streptococcus.

Carbon Nanoparticles Inhibit the Antimicrobial Activities of the Human Cathelicidin LL-37 through Structural Alteration.

Saliva-Derived Host Defense Peptides Histatin1 and LL-37 Increase Secretion of Antimicrobial Skin and Oral Mucosa Chemokine CCL20 in an IL-1-Independent Manner.

In vivo therapeutic efficacy of frog skin-derived peptides against Pseudomonas aeruginosa-induced pulmonary infection.

Identification of bacterial biofilm and the Staphylococcus aureus derived protease, staphopain, on the skin surface of patients with atopic dermatitis.

Vitamin D, Cathelicidin, Prolactin, Autoantibodies, and Cytokines in Different Forms of Pulmonary Tuberculosis versus Sarcoidosis.

LL-37 causes cell death of human nasal epithelial cells, which is inhibited with a synthetic glycosaminoglycan.

Antimicrobial peptides human LL-37 and β-defensin-3 modulate the expression of nerve elongation factors in human epidermal keratinocytes.

The Mla pathway is critical for Pseudomonas aeruginosa resistance to outer membrane permeabilization and host innate immune clearance.

Histones bundle F-actin filaments and affect actin structure.

Antimicrobial cathelicidin peptide LL‑37 induces NET formation and suppresses the inflammatory response in a mouse septic model.

Activated Mesenchymal Stem Cells Interact with Antibiotics and Host Innate Immune Responses to Control Chronic Bacterial Infections.

Vitamin D Levels in Premature Children Admitted to the Hospital with Viral Respiratory Infection.

Characterization of Two Novel Lipopolysaccharide Phosphoethanolamine Transferases in Pasteurella multocida and Their Role in Resistance to Cathelicidin-2.

MEK inhibition enhances efficacy of bacillus Calmette-Guérin on bladder cancer cells by reducing release of Toll-like receptor 2-activated antimicrobial peptides.