15038 studies
INTRODUCTION: The constantly growing resistance of bacteria causing bloodstream infections and the lack of alternative antibiotics generate the need to develop new therapeutic strategies. In this study, the antibacterial properties of synthetic choli…
Human adipose-derived stem cells (hADSCs) exhibit antibacterial properties, but their effectiveness against bacteria resistant to LL-37- a natural human antimicrobial peptide important in the immune defense- is not fully understood. Some bacteria hav…
INTRODUCTION: Biologically active vitamin D (1,25-dihydroxyvitamin D or 1,25D) has emerged as a key regulator of human innate immunity. 1,25D signaling in macrophages strongly induces the expression of neutrophil chemoattractants, such as IL-8/CXCL8.…
Aims/IntroductionVitamin D deficiency is prevalent among individuals with diabetic foot infections (DFIs) and can influence a range of patient-related parameters. Hence, we aimed to find the association of serum vitamin D levels with various clinical…
OBJECTIVE AND DESIGN: We aimed to investigate potential lymphatic vessel abnormalities associated with rosacea and elucidate effective rosacea treatment mechanism using long-pulsed 1064-nm neodymium: yttrium-aluminum-garnet laser (LPND). MATERIAL OR…
The Neisseria gonorrhoeae Type IV pilus is a dynamic fiber involved in host cell attachment, DNA transformation, twitching motility, and evading the innate immune system. We previously reported that pilus expression affects iron homeostasis and sensi…
The development of anticancer peptides (ACPs) has emerged as a promising strategy in targeted cancer therapy due to their high specificity and therapeutic potential. Cathelicidin-derived antimicrobial peptides represent a particularly attractive clas…
Tuberculosis (TB), caused by(MTB), remains one of the most devastating infectious diseases worldwide, with rising multidrug resistance limiting the effectiveness of conventional treatments. Novel therapeutic approaches are urgently needed to compleme…
P2X receptors are a family of ATP-gated ion channels widely distributed in various tissues, especially in neuronal cells and hematopoietic cells. ATP activates P2X receptors, causing the opening of an ionic channel with preferential permeability to t…
Wound healing is a dynamic process involving distinct phases that are regulated by cellular and molecular interactions. This review explores the fundamental mechanisms involved in wound healing, including the roles of cytokines and growth factors wit…
() infection is characterized by a wide spectrum of manifestations, from influenza-like illness to life-threatening atypical pneumonia with multiorgan failure. The aim of our study was the assessment of in vitro and ex vivo neutrophil activation inin…
Cathelicidin-1, an antimicrobial peptide, has garnered attention for its potential role as a biomarker in detecting anestrus in cows, providing insights into bovine reproductive health. This study aimed to analyse cathelicidin-1 within the urinary pr…
causes ocular and other infections and quickly acquires antimicrobial resistance. Polymyxin B and colistin are last-line agents against resistant, yet even resistance to these is increasing. Antimicrobial peptides (AMPs) are also being developed as n…
Psoriasis is an autoimmune disease of the skin with keratinocyte hyperproliferation and increased skin homing of immune cells. LL-37 is an antimicrobial peptide present at a high level in psoriasis patients. It is thought to participate in the induct…
BACKGROUND: Cathelicidin (CAMP), plays important roles in pathogen defense, immune regulation, and epithelial barrier maintenance. While previous studies have highlighted its protective function, the post-translational modifications and downstream im…
Amyloidogenic and antimicrobial peptides (AMPs) share structural and functional similarities, suggesting that AMPs may have evolved from aggregation-prone amyloidogenic precursors through selective incorporation of cationic residues. The core segment…
Peri-implantitis is a major cause of late implant failure and is closely associated with biofilm formation by anaerobic pathogens such as Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola. These bacteria express adhesion protein…
INTRODUCTION: The emergence of antibiotic-resistant pathogens is a significant global health concern that necessitates the development of new antimicrobial drugs. Due to its broad-spectrum action against bacteria, fungi, and viruses, human cathelicid…
INTRODUCTION: Rosacea is a chronic inflammatory skin disorder characterized by symptoms like itching, redness, and impaired skin barrier function. Mast cell activation plays a crucial role in its pathogenesis. Recent evidence shows higher expression…
BACKGROUND: Diabetic urinary incontinence is a multifactorial condition involving neuropathy, oxidative stress, and epithelial dysfunction. Serum biomarkers-cathelicidin (LL-37), elafin, vitamin D receptor (VDR), 4-hydroxynonenal (4-HNE), and amyloid…