15038 studies
Deep skin fungal infections, particularly biofilm-associated(), pose significant clinical challenges due to their resistance to conventional antifungal therapies. The stratum corneum acts as a barrier to high molecular weight drugs, limiting the pene…
The human antimicrobial peptide LL-37 exhibits broad antimicrobial efficacy. However, it has several limitations including high production costs, reduced efficacy under physiological conditions, susceptibility to proteolytic degradation and significa…
BACKGROUND: The genetic modification of mesenchymal stromal/stem cells (MSCs) to express antimicrobial peptides may provide a promising strategy for developing advanced cell-based therapies for bacterial infections, including those caused or complica…
Cathelicidin 3 (CATHL3), a member of the cathelicidin family, exhibits potent resistance against a spectrum of microorganisms. Despite its importance, the expression pattern and regulatory mechanisms of CATHL3 in inflamed dairy mammary glands remain…
OBJECTIVE: To evaluate the effect of the probiotic Bifidobacterium animalis subsp. lactis (B. lactis) HN019, as an irrigation solution, on the expression of neutrophil extracellular traps (NETs) and the antimicrobial peptide CRAMP, in rats with induc…
Cathelicidins are a family of cationic antimicrobial peptides that play a critical role in innate immune defense. Like other antimicrobial peptides, cathelicidins can effectively kill pathogens while minimizing the risk of promoting antimicrobial res…
OBJECTIVES: Rosacea is a chronic inflammatory disease that severely affects the quality of life of patients. Intense pulsed light (IPL) has been widely used in treating the erythema and telangiectasia in rosacea patients. However, the mechanism of it…
BACKGROUND: 1,25(OH)Dsupplementation alone does not provide sufficient benefit to hepatocellular carcinoma (HCC) patients in clinical trials. Tumor-associated macrophages (TAMs)-mediated immunosuppression is regarded as a major hurdle for the effecti…
Human cathelicidin LL-37 is a promising antibacterial agent; however, conventional administration routes limit its efficacy. This study aimed to develop cetyl palmitate (CP)-based lipid nanoparticles loaded with LL-37 peptide (LL) for pulmonary deliv…
This study evaluated the immunomodulatory, antimicrobial, and anticoagulant effects of 1.25-dihydroxy vitamin D3 in neonatal calves with Escherichia coli-induced sepsis. Thirty neonatal Simmental calves were assigned to three groups: Control (n = 10)…
Lacticaseibacillus paracasei cell wall presents two capsular polysaccharides, CPS-1 and CPS-2, and a teichoic acid. CPS-1 is novel and it presents a branched heptasaccharide repeating unit, with the sequence →6)-α-d-Gal-(1→3)-β-l-Rha-(1→4)-β-d-Glc-(1…
Cathelicidin-DM and cathelicidin-BG are homologous and are expected to be similar in structure and biological activity. However, while all structural prediction tools tested showed cathelicidin-BG to be helical, there were mixed results for cathelici…
Niclosamide is an oral anthelmintic agent and was reported to also have anti-inflammatory effects by suppressing STAT3 signaling pathways. In this study, we investigated the effect of niclosamide on skin inflammatory diseases to determine its potenti…
The female genital mucosa expresses the hormone-dependent type I interferon (IFN), IFN-epsilon (IFN-ε), which protects against chlamydia and herpes infection. Surprisingly, we found that IFN-ε knockout (Ifnε) mice and type I IFN receptor knockout (If…
Rosacea is a chronic inflammatory skin disease primarily affecting the central region of the face. Typical manifestations include erythema, papules, or pustules on the cheeks, glabella, chin, and nose, with some patients experiencing ocular involveme…
Biomarkers are necessary tools to validate the diagnosis of Alzheimer's and Parkinson's diseases (AD and PD), especially when clinical symptoms are less apparent in the early stages of diseases. Current biomarkers used in clinical practice rely on br…
Ferroptosis is an important cause of cardiomyocyte loss and cardiac dysfunction. Cathelicidin-related antimicrobial peptide (CRAMP) is an endogenous polypeptide that regulates oxidative stress in the body and is involved in ferroptosis. However, its…
Atopic dermatitis (AD) is a common inflammatory skin condition. Emerging evidence indicates that alterations in the cutaneous expression of the antimicrobial peptide cathelicidin contribute to AD pathogenesis, including weakened skin barrier (SB) fun…
This paper strove to characterize and compare ejaculates collected from two geese breeds over the period of two years in the context of selected traditional, biochemical, oxidative, bacteriological, and immunological properties. Slovak white and Such…
UNLABELLED: Bacteriaewlyeased (NRel) from biofilm residence via multiple methodologies are commonly significantly more sensitive to antibiotics. We've induced NRel with this phenotype after incubation of biofilms formed by diverse human pathogens wit…