Antimicrobial peptide LL-37 disrupts plasma membrane and calcium homeostasis invia the Rim101 pathway.

is a major human fungal pathogen, and antimicrobial peptides are key components of innate immunity. Studying the interplay betweenand human antimicrobial peptides would enhance a better understanding of pathogen-host interactions. Moreover, potential applications of antimicrobial peptides in antifungal therapy have aroused great interest. This work explores new mechanisms of LL-37 againstand reveals the complex connection among calcium homeostasis, oxidative stress, signaling, and possibly organelle interaction. Notably, these findings support the possible use of antimicrobial peptides to prevent and treat fungal infections.