15038 studies
Nanoparticles are prevalent in both commercial and medicinal products; however, the contribution of nanomaterials to carcinogenesis remains unclear. We therefore examined the effects of nano-sized titanium dioxide (TiO(2)) on poorly tumorigenic and n…
Wound healing is an important biological process of crucial value for organisms survival and retention of its proper functions. The recognition of molecular mechanisms of these phenomenon is still under investigation. The transition of mesenchymal fi…
Thymosin beta4 (Tbeta4) is an actin-binding peptide whose expression in developing brain correlates with migration and neurite extension of neurons. Here, we studied the effects of the downregulation of Tbeta4 expression on growth and differentiation…
The spontaneous and unregulated polymerization of actin filaments is inhibited in cells by actin monomer-binding proteins such as profilin and Tbeta4. Eukaryotic cells and certain pathogens use filament nucleators to stabilize actin polymerization nu…
The inability of the human heart to effectively repair itself after acute ischaemic injury has driven the search for efficacious means of promoting cardiac regenerative growth. Central to this has been the emergence of cell-based strategies to stimul…
The deposition of intramuscular adipose fat is an important factor in the quality of beef, particularly in Korean cattle and Japanese cattle. A better understanding of the differential mechanisms regulating the deposition and release of fat between i…
Loss of cells in the human disc due to programmed cell death (apoptosis) is a major factor in the aging and degenerating human intervertebral disc. Our objective here was to determine if thymosin beta(4) (TB4), a small, multifunctional 5 kDa protein…
Fluorescence emission properties of 8-azacaffeine, 8-azatheophylline and other N-alkylated 8-azaxanthines (8-azaXan) have been examined. It is shown that N-methylated 8-azaxanthines, as well as 8-azatheophylline, are highly fluorescent in aqueous med…
This investigation describes the formulation and characterization of rheologically structured vehicles (RSVs) designed for improved drug delivery to the vagina. Interactive, multicomponent, polymeric platforms were manufactured containing hydroxyethy…
Pharmacological sodium nitrate supplementation has been reported to reduce the O2 cost of submaximal exercise in humans. In this study, we hypothesized that dietary supplementation with inorganic nitrate in the form of beetroot juice (BR) would reduc…
Talpha1 (thymosin alpha1), an immune booster, plays an important role in the maturation, differentiation and function of T-cells. It can also activate the production of cytokines in dendritic cells. Talpha1 is one of two thymosin proteins that have p…
OBJECTIVES: To study the effect of immunomodulatory therapy with ulinastatin plus thymosin alpha( 1) on septic patients. METHOD: A total of 56 sepsis patients were randomized into a treatment group, receiving immunomodulatory therapy, and a placebo g…
OBJECTIVE: To assess the effects of thymosin alpha1 to enhance immunity and on the prognosis of sepsis. METHODS: The database from CNKI (1994-2008.10), CBM (1978-2008.10), VIP (1989-2008.10), Wanfang Database (1997-2008.10), PubMed (1966-2008.10), Co…
During brain development, young neurons closely associate with radial glial while migrating from the ventricular zone (VZ) to the cortical plate (CP) of the neocortex. It has been shown previously that gap junctions are needed for this migration to o…
Hepatitis B virus is a crucial public health problem in Pakistan. It has been classified into eight genotypes (A-H) based on genome sequence divergence. Hepatitis B virus genotypes have distinct geographical distributions. Recently genotypes of hepat…
OBJECTIVE: To discuss the effect of continuous blood purification (CBP), thymosin alpha1 and combined therapy on cellular immunity in patients with severe sepsis. METHODS: Ninety-one patients, age over 18 years, suffering from severe sepsis with Mars…
OBJECTIVE: To analyze clinical effect of immuno-modulatory therapy with ulinastatin and thymosin alpha1 on patients with sepsis. METHODS: Two hundred and forty-two septic patients admitted to Guangzhou General Hospital of Guangzhou Military Command i…
N(alpha)-Acetylation is one of the most common protein modifications in eukaryotes but a rare event in prokaryotes. Some endogenously N(alpha)-acetylated proteins in eukaryotes are frequently reported not to be acetylated or only very partially when…
We investigated the effects of the in vivo administration of thymosin alpha-1 (Talpha-1) on streptozotocin (STZ)-induced pancreatic lesions and diabetes. Mice were randomly divided into four experimental groups: normoglycemic control, STZ-treated, ST…
BACKGROUND: Thymosin alpha(1) (Talpha(1)), a synthetic version of a thymic-derived biological response modifier was the first of the thymosins in clinical use. Talpha(1) is approved in over 35 countries for the treatment of hepatitis B and C, and as…