The only human cathelicidin antimicrobial peptide, playing key roles in innate immune defense, wound healing, and modulation of inflammatory responses.
(1) Background: In recent years, there has been a growing interest in understanding the innate immunity of the mouth, particularly the mechanisms through which vitamin D influences oral health. Researchers have increasingly focused on the association…
Non-canonical functions of olfactory receptors, one of the largest families of GPCR receptors not confined to the olfactory system, include an intriguing role on hair physiology. Previous studies using odorant agonists of the Olfactory Receptor famil…
Tuberculosis (TB), caused by(MTB), remains one of the most devastating infectious diseases worldwide, with rising multidrug resistance limiting the effectiveness of conventional treatments. Novel therapeutic approaches are urgently needed to compleme…
Sepsis and septic shock are major complications of febrile neutropenia (FN) in pediatric patients with cancer (PPCs). The aim of the present study was to determine the association of vitamin D (VD) and cathelicidin levels with sepsis and septic shock…
This study aims to investigate the effect of different levels of zinc oxide quantum dots (ZnO-QDs) on the growth performance and gut health in broilers. A total of 1125 1-day-old Ross 308 broilers were randomly divided into five groups with 15 replic…
Antimicrobial peptides (AMPs) are crucial constituents of inherent immunity and serve as vital components of human host defense, playing a pivotal role in combating invading microbial pathogens. Beyond their antimicrobial functions, AMPs also exhibit…
The emergence of multidrug-resistant (MDR) bacterial pathogens is an alarming global health threat that demands new therapeutic strategies beyond conventional antibiotics. Here, we present a rationally designed antimicrobial peptide (AMP) derived fro…
Poultry are susceptible to oxidative stress, which decreases immune function and negatively affects production performance under highly intensive feeding conditions. Moreover, anthocyanins can alleviate oxidative stress and improve immune functions i…
In this narrative review, we examined observational and randomized controlled trials investigating the effects of fermented dairy foods, including yogurt, fermented milk, kefir, and cheese, on gastrointestinal (GI) symptoms and/or GI biomarkers of he…
is a major cause of necrotizing enteritis in chickens. This study aimed to investigate the effects of zinc oxide quantum dots (ZnO-QDs) on growth performance, redox status, and gut microbiota in broilers challenged with. A total of 320 1-day-old chic…
Candida glabrata (currently classified as Nakaseomyces glabratus) is an opportunistic yeast-like fungus that causes infections in humans, with limited treatment options due to resistance to antifungal drugs. In contrast to C. albicans, which produces…
UNLABELLED: Autoimmune skin diseases, such as psoriasis are primarily characterized by excessive inflammation and skin barrier damage. The disrupted skin barrier is directly related to skin dryness. Luteolin, a flavonoid compound, has various biologi…
BACKGROUND: To conduct a comprehensive bibliometric analysis of LL-37, summarize its development trends and patterns, and identify emerging research hotspots. METHODS: Bibliometric and Knowledge Graph Analysis of Literature Data Related to LL-37 in t…
The intestinal barrier, held together by epithelial cells and intercellular tight junction (TJ) proteins, prevents the penetration of microbial pathogens. Concurrently, intestinal epithelial cells secrete antimicrobial peptides, including cathelicidi…
Cathelicidin 3 (CATHL3), a member of the cathelicidin family, exhibits potent resistance against a spectrum of microorganisms. Despite its importance, the expression pattern and regulatory mechanisms of CATHL3 in inflamed dairy mammary glands remain…
BACKGROUND: Human cathelicidin LL-37 shows activity towards both gram-positive and gram-negative bacteria, and it is also active against some types of viruses. Besides its antimicrobial effects, the peptide modulates innate immunity through binding a…
Implant-associated infections pose significant challenges due to bacterial resistance to antibiotics. Recent research highlights the potential of immobilizing antimicrobial peptides (AMPs) onto implants as an alternative to conventional antibiotics f…
Brachymystax lenok is an economically valuable cold-water fish species that has shown lower morbidity during pathogen outbreaks compared to other cold-water species. To elucidate the innate immune mechanisms in B. lenok in response to Aeromonas salmo…
UNLABELLED: Bacteriaewlyeased (NRel) from biofilm residence via multiple methodologies are commonly significantly more sensitive to antibiotics. We've induced NRel with this phenotype after incubation of biofilms formed by diverse human pathogens wit…
The authors explored the genomic landscape of bat cathelicidins, critical proteins in the vertebrate innate immune system, across 41 bat species, which are notable for their high microbial tolerance. An array of bioinformatics tools, complemented by…