Review examining MOTS-c's diverse cardioprotective mechanisms in diabetic cardiomyopathy—covering its anti-inflammatory, anti-apoptotic, anti-fibrotic, and metabolic-restoring properties across T1DM and T2DM animal models—and arguing that MOTS-c addresses the multifactorial pathophysiology of diabetic cardiac disease more comprehensively than single-target drugs. Positions MOTS-c as a 'magical molecule' for diabetic cardiac protection. Provides a synthesis of the diabetic cardiomyopathy-specific MOTS-c literature—consolidating evidence that mitochondrial peptide supplementation can simultaneously address the energy deficit, inflammation, fibrosis, and cell death that collectively drive diabetic heart failure.
Yerra, Veera Ganesh; Connelly, Kim A