A nanoparticle platform for combined mucosal healing and immunomodulation in inflammatory bowel disease treatment.

Bioactive materials2024PMID: 37859689

View on PubMed DOI: 10.1016/j.bioactmat.2023.09.014

Plain Language Summary

Nanoparticles coated with a hyaluronic acid-KPV combination were loaded with teduglutide, a peptide that promotes intestinal tissue growth, to create a dual-action treatment for inflammatory bowel disease. The KPV coating determined whether the nanoparticles suppressed immune responses — particles without it provided tissue healing but no immunosuppression, while those with it did both. The platform demonstrates how peptide surface modifications can tune the therapeutic profile of drug delivery systems.

Abstract

Current treatments for inflammatory bowel disease (IBD) treatment consist of anti-inflammatory products. In this study, we sought to induce the physiological secretion of glucagon-like peptide 2, a peptide with intestinal growth-promoting activity, via nanoparticles while simultaneously providing with immunomodulation by tailoring the nanoparticle surface. To this end, we developed hybrid lipid hyaluronate-KPV conjugated nanoparticles loaded with teduglutide for combination therapy in IBD. The nanocarriers induced (or did not induce) immunosuppression depending on the presence (or absence) of a hyaluronan-KPV functionalization. This strategy holds promise as a nanoparticle platform for combined mucosal healing and immunomodulation in IBD treatment.

Authors

Marotti, Valentina; Xu, Yining; Bohns Michalowski, Cécilia; Zhang, Wunan; Domingues, Inês; Ameraoui, Hafsa; Moreels, Tom G; Baatsen, Pieter; Van Hul, Matthias; Muccioli, Giulio G; Cani, Patrice D; Alhouayek, Mireille; Malfanti, Alessio; Beloqui, Ana

Keywords

GLP-2Inflammatory bowel diseaseKPVNanocarrierTeduglutide