A review article specifically examining BPC 157's mechanism of activating collateral vascular pathways. Proposes that BPC 157's broad cytoprotective effects across organ systems—GI tract, brain, heart, liver, kidneys—are unified by a single mechanism: prompt activation of alternative (collateral) circulatory routes when primary vessels are occluded or failing. Frames BPC 157 as a vascular rescue agent that restores blood flow through bypass pathways rather than treating individual organs in isolation.
Sikiric, Predrag; Gojkovic, Slaven; Knezevic, Mario; Tepes, Marijan; Strbe, Sanja; Vukojevic, Jaksa; Duzel, Antonija; Kralj, Tamara; Krezic, Ivan; Zizek, Helena; Oroz, Katarina; Vranes, Hrvoje; Smoday, Ivan Maria; Kalogjera, Luka; Vlainic, Josipa; Kokot, Antonio; Jurjevic, Ivana; Blagaic, Alenka Boban; Skrtic, Anita; Seiwerth, Sven