State of Colon Microbiota in Rats during Chronic Restraint Stress and Selank Treatment.

Bulletin of experimental biology and medicine2019PMID: 31236882

View on PubMed DOI: 10.1007/s10517-019-04496-y

Animal StudySelank

Plain Language Summary

Studies Selank's effect on gut microbiota composition in chronically stressed rats. Restraint stress reduced beneficial obligate bacteria and increased opportunistic pathogens in the colon. Selank treatment restored the microbiota balance, likely through central (reducing stress hormones) and peripheral (immunomodulatory) mechanisms—linking anxiety treatment with microbiome health.

Abstract

We studied the effects of Selank on intestinal microbiota in Wistar male rats subjected to chronic restraint stress. Selank was injected intraperitoneally in doses of 80, 250 and 750 μg/kg 15 min before stress exposure. Chronic restraint stress led to a decrease in the content of obligate microflora, while the content of opportunistic microorganisms increased. Selank restored intestinal microbiota presumably via central (neurotropic) and peripheral (immunotropic) mechanisms.

Authors

Mukhina, A Yu; Medvedeva, O A; Svishcheva, M V; Shevchenko, A V; Efremova, N N; Bobyntsev, I I; Kalutskii, P V; Andreeva, L A; Myasoedov, N F

Keywords

Selankdysbiosismicrobiotarestraint stress