Experimental Substantiation of Application of Semax as a Modulator of Immune Reaction on the Model of "Social" Stress.

Bulletin of experimental biology and medicine2019PMID: 31028579

View on PubMed DOI: 10.1007/s10517-019-04434-y

Plain Language Summary

Social stress in laboratory animals suppressed some immune responses while amplifying others — a pattern consistent with "immune imbalance" seen under stress conditions. Semax restored both cellular and antibody-based immune function and normalized the activity of infection-fighting white blood cells. The findings confirm that Semax has genuine immunomodulatory properties and warrants further study as a therapeutic for stress-related immune dysfunction.

Abstract

We studied immunocorrecting effects of Semax (Met-Glu-His-Phe-Pro-Gly-Pro) on the model of "social" stress caused by sensory contact and intermale confrontation. Functional activity of the immune system of laboratory animals was evaluated in standard immunopharmacological tests: delayed-type hypersensitivity reaction, direct agglutination test, latex test for studying phagocytic activity of peripheral blood neutrophils, changes in differential leukocyte count, and weight of immunocompetent organs. It was found that changes in the immune response caused by "social" stress are multidirectional, which confirms the theory of stress-induced "immune imbalance". Semax acted as effective immune corrector restoring cellular and humoral immunogenesis reactions and phagocytic activity of neutrophils. This attested to the presence of immunomodulating properties in Semax and necessitates further studies in this field.

Authors

Samotrueva, M A; Yasenyavskaya, A L; Murtalieva, V Kh; Bashkina, O A; Myasoedov, N F; Andreeva, L A; Karaulov, A V

Keywords

Semaximmune systemsensory contactsocial stress