[Effect of peptide geroprotectors on the navigation system learning and caspase-3 in brain structures in rats of different age].

Advances in gerontology = Uspekhi gerontologii2013PMID: 28976148

Animal StudyPinealon

Plain Language Summary

In rats of different ages, the peptide Pinealon improved spatial learning performance in the Morris water maze more effectively than Cortexin, particularly in older animals. The effects were associated with regional changes in caspase-3 activity, an enzyme involved in programmed cell death, in different brain areas. The results suggest that the brain's caspase-3 status partly determines an animal's capacity to learn and that Pinealon can favorably shift this.

Abstract

The study of the effects of peptide geroprotectors cortexin and pinealon on the system of caspase-3 in the brain structures and training of rats of different ages was held. Regional changes in activity and the content of caspase-3 in the cerebral cortex and brainstem of young and old rats under the influence of peptides were identified. It is suggested that the functional state of caspase-3 in the brain is one of the reasons that determines the animals' ability to learn. Pinealon has prevalent positive effect on learning of both young and old animals in the Morris labyrinth compared to cortexin.

Authors

Mendzheritski, A M; Karantysh, G V; Abramchuk, V A; Ryzhak, G A

Keywords

caspase-3peptide geroprotectorsrats of different agestraining