[Pinealon and Cortexin influence on behavior and neurochemical processes in 18-month aged rats within hypoxia and hypothermia].

Advances in gerontology = Uspekhi gerontologii2015PMID: 28509493

Animal StudyPinealon

Plain Language Summary

In 18-month-old rats subjected to either oxygen deprivation or cold stress, the peptide preparations Pinealon and Cortexin each produced distinct neurochemical changes that appeared to underlie their protective effects. Cortexin more strongly reduced free radical activity and programmed cell death markers in the brain, while both peptides boosted levels of key neurotransmitters under stress conditions. The differing neurochemical profiles suggest the two peptides have complementary geroprotective mechanisms.

Abstract

The research of Cortexin and Pinealon within two models of stress, acute hypobaric hypoxia and mild hypothermia, within 18-month aged rats has been held. The peculiarities of peptide preparations' influence on behavior and neurochemical indeces have been identified. Cortexin shows a more pronounced effect on free radical processes and caspase 3 activity in brain than Pinealon. Both preparations forward an accumulation of adrenergic mediator within rats' brains in the model of acute hypobaric hypoxia, as well as serotonin within cerebrum cortex in the model of mild hypothermia, which may underlie their geroprotective effects.

Authors

Mendzheritsky, A M; Karantysh, G V; Ryzhak, G A; Prokofiev, V N

Keywords

CortexinPinealonbehaviorcaspase-3free radical processeshypobaric hypoxiamild hypothermianeuromediators