Effect of Selank on Spontaneous Synaptic Activity of Rat Hippocampal CA1 Neurons.

Bulletin of experimental biology and medicine2017PMID: 28361410

View on PubMed DOI: 10.1007/s10517-017-3676-3

Animal StudySelank

Plain Language Summary

A slice electrophysiology study measuring Selank's direct effect on hippocampal CA1 neurons. Selank application increased both amplitude and frequency of spontaneous inhibitory postsynaptic currents (IPSCs)—the signals transmitted by GABA-releasing neurons. This provides direct mechanistic evidence that Selank enhances GABAergic inhibitory neurotransmission in the hippocampus, consistent with its anxiolytic clinical effects.

Abstract

Application of anxiolytic drug Selank to hippocampal slices increased the amplitude and discharge rate of spontaneous inhibitory postsynaptic currents in rat hippocampal pyramidal CA1 neurons. In some neurons, Selank-induced up-regulation of spontaneous inhibitory postsynaptic currents was preceded by a transient decrease in this activity. In the examined concentration range (1-8 μM), Selank demonstrated no significant dose-dependence.

Authors

Povarov, I S; Kondratenko, R V; Derevyagin, V I; Myasoedov, N F; Skrebitsky, V G

Keywords

Selankanxiolytic drugshippocampusspontaneous activity