Semax prevents learning and memory inhibition by heavy metals.

Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections20164 citationsPMID: 27411820

View on PubMed DOI: 10.1134/S0012496616030066

Animal StudySemax

Plain Language Summary

Showed Semax prevents learning and memory inhibition by heavy metals in rats. The peptide counteracted lead and molybdenum-induced avoidance response inhibition as effectively as ascorbic acid, demonstrating cognitive protective properties.

Abstract

Separate and joint effect of Semax, ascorbic acid, lead diacetate, and ammonium molybdate on avoidance conditioning in rats was studied. It was established that the heavy metal salts inhibited the avoidance response, and the peptide counteracted this inhibition as strongly as ascorbic acid or to a comparable degree. These findings confirm the antioxidant properties of Semax.

Authors

Inozemtsev, A N; Bokieva, S B; Karpukhina, O V; Gumargalieva, K Z; Kamensky, A A; Myasoedov, N F