Short Peptides and Telomere Length Regulator Hormone Irisin.

Bulletin of experimental biology and medicine2016PMID: 26742748

View on PubMed DOI: 10.1007/s10517-016-3167-y

Plain Language Summary

The exercise hormone irisin, which promotes fat burning and has anti-aging effects, can be regulated at the gene level by specific short peptides. The peptides Lys-Glu and Glu-Asp-Arg appear to modulate irisin gene expression, potentially contributing to their known lifespan-extending and geroprotective effects. This connection links peptide bioregulation to a key pathway involved in the health benefits of physical activity.

Abstract

Irisin produced by muscles during exercise and promoting fat burning also exhibits geroprotective effect and induces telomere elongation in normal somatic cells. Special attention is paid to studies of the role of peptides Lys-Glu, Glu-Asp-Arg, and Ala-Glu-Asp-Gly in epigenetic regulation of irisin content. The data suggest that the immunomodulatory peptide Lys-Glu and neuroprotective peptide Glu-Asp-Arg modulate the life span by modulating irisin gene expression.

Authors

Khavinson, V Kh; Kuznik, B I; Tarnovskaya, S I; Lin'kova, N S

Keywords

epigeneticsirisinshort peptidestelomeres