Effects of Geroprotectors on Age-Related Changes in Proteolytic Digestive Enzyme Activities at Different Lighting Conditions.

Bulletin of experimental biology and medicine2015PMID: 26519279

View on PubMed DOI: 10.1007/s10517-015-3069-4

Animal StudyEpitalon

Plain Language Summary

Researchers studied how light conditions and aging affect digestive enzyme activity in rats, and whether melatonin and Epitalon could help. Constant light disrupted the normal age-related changes in digestive enzymes, but administration of melatonin and Epitalon helped restore the normal age-related patterns of pepsin activity in rats exposed to constant light.

Abstract

We studied the effect of melatonin and epithalon on age-related changes in proteolytic digestive enzyme activity in the pancreas and gastric mucosa of rats kept under different lighting conditions. In rats kept under standard illumination, pepsin activity and the total proteolytic activity in the stomach and pancreas increased by the age of 12 months, but then decreased. Constant and natural lighting disturbed the age dynamics of proteolytic digestive enzyme activity. Administration of melatonin and epithalon to animals exposed to constant lighting restored age dynamics of pepsin activity and little affected total proteolytic activity.

Authors

Morozov, A V; Khizhkin, E A; Svechkina, E B; Vinogradova, I A; Ilyukha, V A; Anisimov, V N; Khavinson, V Kh

Keywords

agingepithalonillumination regimesmelatoninproteolytic digestive enzymes