[The comparison of neuroprotective action of antibodies to glutamate and drug preparation semax in the focal ischemic damage of the brain prefrontal cortex of rats].

Patologicheskaia fiziologiia i eksperimental'naia terapiia2012PMID: 23072114

Animal StudySemax

Plain Language Summary

After surgically inducing strokes in both frontal lobes of rats, both Semax and antibodies to glutamate (AB-Glu) were given intranasally and compared for neuroprotective and memory-sparing effects. Both treatments reduced the volume of brain damage and preserved the rats' ability to recall a learned avoidance response that was trained before the stroke. The results suggest that intranasal delivery of both compounds offers comparable neuroprotection against this type of frontal cortex injury.

Abstract

It was stated, that with bilateral photochemically induced thrombosis of the prefrontal cortex peptide semax and the AB-Glu by intranasal injection provoke pronounced neuroprotective and antiamnestic action. Intranasal injection semax (250 mkg/kg/daily during six postoperative days) and AB-Glu (250 mkg/kg in 1 hour after phototrombosis) demonstrate diminishing of cortex damage volume and relieve preservation and reproduction rat passive avoidance reflex, acquired before bilateral photochemically induced thrombosis of prefrontal cortex.

Authors

Romanova, G A; Shakova, F M; Davydova, T V