Studies Selank's effects on carboxypeptidase H and PMSF-inhibited carboxypeptidase—enzymes that cleave arginine and lysine from neuropeptide precursors. Single Selank administration caused long-lasting (24 h) changes in enzyme activity in rat nervous tissue. Proposes that modulating these neuropeptide-processing enzymes is one mechanism by which Selank shifts the balance of endogenous biologically active peptides to produce its effects.
Solov'ev, V B; Gengin, M T; Sollertinskaia, T N; Latynova, I V; Zhivaeva, L V