[Peptidergic modulation of the hippocampus synaptic activity].

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova2011PMID: 22390072

Plain Language Summary

An electrophysiology study using patch-clamp recording in hippocampal brain slices, comparing how Noopept and Selank affect inhibitory synaptic transmission. Both peptides increased the frequency of action-potential-dependent inhibitory currents in hippocampal CA1 neurons, suggesting they activate inhibitory interneurons. Provides direct cellular evidence that both nootropic peptides enhance inhibitory (GABAergic) tone in the hippocampus.

Abstract

Effects of two newly synthesized nootropic and anxiolytic dipeptides: Noopept and Selank on inhibitory synaptic transmission in hippocampal CA1 pyramidal cells were investigated using patch-clamp technique in whole-cell configuration. Bath application of Noopept (1 microM) or Selank (2 microM) significantly increased the frequency of spike-dependent spontaneous m1PSCs, whereas spike-independent mlPSCs remained unchanged. It was suggested that both peptides mediated their effect sue to activation of inhibitory interneurons terminating on CA1 pyramidal cells. Results of current clamp recording of inhibitory interneurons residing in stratum radiatum confirmed this suggestion, at least for Noonent.

Authors

Skrebitskiĭ, V G; Kondratenko, R V; Povarov, I S; Dereviagin, V I