[The influences of geroprotectors on age-related changes of antioxidant system in rats liver under different light condition].

Advances in gerontology = Uspekhi gerontologii2008PMID: 19432171

Animal StudyEpitalon

Plain Language Summary

This study examined how different lighting conditions and the aging protectors melatonin and Epitalon affect the liver's antioxidant defenses in rats over time. Constant light exposure caused the most significant disruptions to antioxidant enzyme levels, while both melatonin and Epitalon helped modulate age-related changes depending on the specific lighting and sex of the animals.

Abstract

The influences of different light condition, melatonin and epithalon on liver antioxidant system in 6-, 12-, 18- and 24-month-old rats of both sexes were studied. The activities of antioxidant enzymes as well as concentration of tocopherol demonstrate high stability. The maximal number of significant changes in antioxidant system parameters was found under continuous light exposure. Light condition, sex and preparation modulated age-related changes of antioxidant system.

Authors

Il'ina, T N; Vinogradova, I A; Iliukha, V A; Khizhkin, E A; Anisimov, V N; Khavinson, V Kh