Audiogenic epilepsy in young mice of different strains after neonatal semax treatment.

Bulletin of experimental biology and medicine2008PMID: 19145359

Animal StudySemax

Plain Language Summary

This study examined audiogenic epilepsy in young mice of different strains after neonatal Semax treatment. The ACTH(4-10) analogue produced strain-dependent effects on seizure susceptibility, revealing lasting influences of early neuropeptide exposure on brain excitability.

Abstract

Neonatal (from day 2 to day 7 of life) injection of neuropeptide semax to mice of 5 inbred strains significantly reduced predisposition to audiogenic epilepsy in only one-month-old DBA/2J mice, which manifested in changes in the mean audiogenic sensitivity score and percentage of animals dead as a result of acoustic stimulation.

Authors

Boyarshinova, O S; Perepelkina, O V; Markina, N V; Poletaeva, I I