[Circannual rhythms of bone marrow cell composition in animals during aging: the role of pineal factors].

Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)2007PMID: 18309632

Animal StudyEpitalon

Plain Language Summary

Aging mice showed disrupted seasonal rhythms in bone marrow cell populations. Treatment with the pineal extract Epithalamin helped restore many of these rhythms to patterns seen in younger animals, while Epitalon showed similar but less pronounced effects. The improvements are likely related to better regulation of hormones and brain chemistry.

Abstract

It was investigated the influence of pineal gland's peptides (epithalamin, epithalon) and indols (melatonin) on the aging changes of circannual rhythms of stromal cells-precurcors (CFC-F), granulocyte-macrophage cells-precurcors (CFC-GM), CD4+, Mac-1+ and CD19+-cells amount in bone marrow of mice CBA. In old animals the rhythmical disturbances of the indices were characterized by loss of fluctuations (Mac 1+-cells), increase of CD4+-cells amplitude, displacement of seasonal acrophase (CFC-F), inversion of rhythm (CFC-GM), desynchronization. In old mice after epithalamin injections the season differences between the amount of Mac-1+-cells restored, CD4+-cells amplitude diminished, the amount of CFC-GM increased in spring and CFC-F diminished in autumn. The influence of epithalon on CFC-F and CFG-GM rhythm was in a smaller dose. The rhythms of some indices in old animals showed a pattern observed in adults. After melatonin injections to adult mice in winter the amount of CD4+-cells increased; the ratio CFC-GM and CFC-F changed because of increase of stromal fibroblasts. In old mice the indices were without changes.

Authors

Labunets', I F