Interleukin-2 concentration in hypothalamic structures of rats receiving peptides during mild stress.

Bulletin of experimental biology and medicine2006PMID: 17152351

Animal StudyEpitalon

Plain Language Summary

Epitalon altered the number of interleukin-2-containing cells in rat hypothalamic structures during mild stress. The effect varied depending on the route of administration and timing, with intranasal delivery producing faster changes. Animals that had adapted to the experimental conditions showed different responses, suggesting the peptide's effects are context-dependent.

Abstract

The number of hypothalamic IL-2-containing cells changed in rats receiving Vilon and Epithalon during mild stress (handling). The number of IL-2-positive cells in hypothalamic structures decreased 24 h after intramuscular injection of Epithalon and 2 h after intranasal administration of the test peptides. Adaptation of animals to experimental conditions prevented the decrease in the number of IL-2-positive cells in the supraoptic nucleus after intranasal administration of Epithalon.

Authors

Barabanova, S V; Artyukhina, Z E; Kazakova, T B; Khavinson, V Kh; Malinin, V V; Korneva, E A