C-terminal Pro-Gly-Pro tripeptide in contrast to full-length neuropeptide semax exhibits no neuroprotective effect in experimental cerebral ischemia.

Bulletin of experimental biology and medicine20051 citationPMID: 16027870

Animal StudySemax

Plain Language Summary

This study found that the C-terminal Pro-Gly-Pro tripeptide fragment of Semax, in contrast to full-length Semax, exhibits no neuroprotective effect in experimental cerebral ischemia. This demonstrates that the complete heptapeptide sequence is required for Semax's brain-protective properties.

Abstract

The C-terminal fragment Pro-Gly-Pro of semax does not modulate the development of symptoms of neurological deficiency and mortality in rats with incomplete global cerebral ischemia. Hence, previously revealed neuroprotective effects of semax are mainly determined by corticotropin ACTH4-7 fragment.

Authors

Fadyukova, O E; Kadi, A; Bai, Ou; Andzhusheva, G M; Koshelev, V B