[Effect of new synthetic anxiolytic selank on gastric wall blood flow and mesenteryc lymphatic vessels contractility in anesthetized rats].

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova2005PMID: 15835541

Animal StudySelank

Plain Language Summary

Examines Selank's effects on gastric blood flow and mesenteric lymphatic vessel contractility in rats. Selank had no effect on baseline gastric blood flow but normalized flow reduced by indomethacin (an NSAID). Selank also enhanced lymphatic vessel contractility at very low concentrations (10⁻¹²–10⁻¹⁴ M), suggesting it promotes lymphatic drainage and tissue fluid balance—mechanisms supporting its antiulcer effects.

Abstract

The influence of a new heptapeptide Selank on microcirculation in anesthetized white rats was investigated. Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a new synthetic anxiolytic which exerts obvious antiulcerogenic action and promotes healing of experimental ulcers. Action of the peptide on gastric blood flow in the stomach by using the method ofhydrogenic clearance and Selank action on mesenteric lymphatic contractility by microscopical observation in situ, were studied. Selank fail to influence basal gastric blood flow but it can normalize blood flow reduced by indomethacin. The study of dose-depended of Selank effect on lymphatic vessels contractility showed that its low concentration (10(-12)--10(-14) M) enhanced amplitude and increase frequency of lymphatic vessel contractions which indicates an enhancement of lymphatic flow. The high doses of peptide (10(-6)--10(-10) M) also augmented the contraction amplitude but decreased its frequency. The maintenance of adequate blood flow and lymphatic vessel contractility can be one of the mechanisms of the Selank antiulcerogenic properties.

Authors

Pavlov, T S; Sanzhieva, L Ts; Samonina, G E; Sergeev, V I; Lelekova, T V