[Pharmacological correction of memory impairment caused by a complex extremal action in mice with bilateral ligation of common carotid arteries].

Eksperimental'naia i klinicheskaia farmakologiia2004PMID: 15559625

Animal StudySemax

Plain Language Summary

This study evaluated Semax's ability to correct memory impairment caused by complex extreme stress in mice with bilateral common carotid artery ligation. The nootropic peptide showed pharmacological protection against memory deficits arising from combined cerebrovascular insufficiency and stress.

Abstract

Semax and mexidol significantly increase the survival of white mongrel male mice upon bilateral ligation of common carotid arteries. Semax virtually completely prevented retrograde amnesia development in ligated mice under conditions of a complex extremal action (emaciating swim in cold water with simultaneous wheel rotation) and increased the lifetime of these animals in altitude test chamber.

Authors

Iasnetsov, V V; Ivanov, Iu V