[The influence of substances revealing geroprotective of spontaneous carcinogenesis in mice].

Advances in gerontology = Uspekhi gerontologii2004PMID: 15559508

ReviewAnimal StudyEpitalon

Plain Language Summary

This review summarizes experiments showing that several geroprotective substances, including Epitalon, melatonin, and delta-sleep-inducing peptide, inhibited age-related reproductive decline and spontaneous tumor development while extending lifespan in various mouse strains. The effects depended on dose, administration method, and the genetic background of the mice.

Abstract

The review presents the results of experimental studies conducted by the author. CBA, SHR, HER-2/neu and SAM mice revealed inhibition of age-related alterations in estrus function and spontaneous tumour development and showed life span extension under the influence of the pineal gland hormone Melatonin, synthetic peptide bioregulator Epitalon, delta-sleep-inducing peptide Deltaran, enterosorbent Aqualen and succinic acid containing preparation Neuronol (Noogam). The observed effect depended on the dose and conditions of administration, as well as genetic predisposition of the particular mice strains to tumour development.

Authors

Popovich, I G