[Effect of epitalon on the immunity and hemostasis in hypophysectomized chicken and old hens].

Advances in gerontology = Uspekhi gerontologii2004PMID: 15490730

Plain Language Summary

Epitalon reversed immune deficiency, blood clotting disorders, and anemia caused by pituitary gland removal in young chickens. The same peptide also corrected similar but milder abnormalities in old hens, with stronger effects seen in the surgically altered young birds.

Abstract

Neonatal hypophysectomy in chicken, as well as that in old hen has been established to entail in 1,5 months after surgery cellular and humoral immunity disturbances, pronounced hypercoagulation and fibrinolysis depression. Administration of Epitalon (Ala-Glu-Asp-Gly) to a large extent eliminates revealed shifts. This effect appeared to be stronger in neonatally hypophysectomized chicken than in old hens.

Authors

Kuznik, B I; Pateiuk, A V; Khavinson, V Kh; Malinin, V V