Expression of argyrophilic proteins in the nucleolar organizer regions of human thymocytes and thymic epitheliocytes under conditions of coculturing with vilon and epithalon peptides.

Bulletin of experimental biology and medicine2004PMID: 15455093

Plain Language Summary

Epitalon and Vilon had opposite effects on protein synthesis machinery in human thymus cells. Vilon stimulated the production and transport of ribosomes and promoted cell proliferation, while Epitalon suppressed ribosome-related protein activity, demonstrating that these peptides have distinct and complementary roles in regulating thymus cell function.

Abstract

Vilon stimulated and Epithalon suppressed the expression of argyrophilic proteins in nucleolar organizer regions of thymocytes and epithelial cells, stimulating or reducing, respectively, the formation, assembly, and transport of ribosomes into the cytoplasm and thus determining the intensity of protein synthesis in these cells. A direct mitogenic effect of Vilon was also revealed: this peptide promoted thymocyte transformation into proliferating blast cells.

Authors

Raikhlin, N T; Bukaeva, I A; Smirnova, E A; Yarilin, A A; Sharova, N I; Mitneva, M M; Khavinson, V Kh; Polyakova, V O; Trofimov, A V; Kvetnoi, I M