Genotype-dependent changes in pain thresholds in adult mice after neonatal treatment.

Bulletin of experimental biology and medicine20043 citationsPMID: 15455076

Animal StudySemax

Plain Language Summary

This study revealed genotype-dependent changes in pain thresholds in adult mice that received neonatal Semax treatment. The long-lasting effects of early-life neuropeptide exposure on pain sensitivity varied by genetic background, demonstrating enduring epigenetic-like effects of Semax.

Abstract

We studied the effect of neonatal treatment with pharmacological preparations (Semax and buspiron) and solvents (distilled water and physiological saline) on the pain threshold in 3-4-month-old mice of 6 genotypes. Neonatal administration of the solvent (nociceptive stimulation) decreased pain thresholds in DBA/2, 101/HY, and RSB males, but not in female mice and animals of other strains. Neonatal administration of Semax significantly increased pain thresholds in adult DBA/2 and 101/HY males compared to those in animals neonatally treated with the solvent. Injection of buspiron in the neonatal period decreased pain thresholds in RLB males.

Authors

Boyarshinova, O S; Shilova, O B; Markina, N V; Gichenok, I V; Perepelkina, O V; Poletaeva, I I