Secretory activity of mast cell during stress: effect of prolyl-glycyl-proline and Semax.

Bulletin of experimental biology and medicine20033 citationsPMID: 14714073

Animal StudyIn VitroSemax

Plain Language Summary

This study examined how Semax affects mast cell secretory activity during stress. The neuropeptide and the related peptide prolyl-glycyl-proline modulated mast cell degranulation under stress conditions, suggesting a mechanism by which Semax influences inflammatory and stress responses.

Abstract

Stress increased secretory activity of mast cells in the mesentery and subcutaneous fat of rats. Intraperitoneal injection of Semax and prolyl-glycyl-proline in doses of 0.05 and 1 mg/kg, respectively, 1 h before stress abolished this effect. The test preparations did not modulate secretory activity of mast cells in unstressed animals. Semax and prolyl-glycyl-proline in vitro prevented activation of mast cells with synacten and acetylcholine. The stabilizing effect of peptides on mast cells probably determines their antiulcer activity.

Authors

Umarova, B A; Kopylova, G N; Smirnova, E A; Guseva, A A; Zhuikova, S E