Retinoprotective effect of Epithalon in campbell rats of various ages.

Bulletin of experimental biology and medicine2003PMID: 12910293

Animal StudyEpitalon

Plain Language Summary

Epitalon preserved retinal structure and function in Campbell rats with hereditary retinal degeneration when given both before and after birth. Rats treated from conception showed twice the protection compared to controls, and 30% more than those treated only after birth, suggesting early intervention maximizes the peptide's retina-protective benefits.

Abstract

We studied the retinoprotective effect of Epithalon administered to the offspring of Campbell rats during postnatal ontogeny and to mothers before mating and during pregnancy. After this treatment the morphological structure and functional activity of the retina were preserved for a longer period compared to control rats (by 2 times) and to the animals receiving the peptide only during postnatal ontogeny (by 30%).

Authors

Khavinson, V Kh; Razumovsky, M I; Trofimova, S V; Razumovskaya, A M