Therapy of peptic ulcer with semax peptide.

Bulletin of experimental biology and medicine20022 citationsPMID: 12459874

Plain Language Summary

This study evaluated Semax peptide as a therapy for peptic ulcer disease. The ACTH(4-10) analog demonstrated ulcer-healing properties, supporting the concept that neuropeptides with regulatory and protective functions can be therapeutically applied to gastrointestinal disorders.

Abstract

Experiments used is combination with traditional preparations (omeprasole, de-nol, and solcoseril), Semax peptide (Met-Glu-His-Phe-Pro-Gly-Pro) possessing nootropic and neuroprotective activity significantly promoted ulcer healing in patients with refractory peptic ulcers. On day 14 of treatment ulcer healing was observed in 89.5% patients receiving intranasal Semax (1% solution, 2-4 drops 3 times a day for 10 days) vs. 30.8% in the control group. Clinical studies of antiulcer activity of Semax in different combinations with usual antiulcer drugs are needed.

Authors

Ivanikov, I O; Brekhova, M E; Samonina, G E; Myasoedov, N F; Ashmarin, I P