In vitro effect of short peptides on expression of interleukin-2 gene in splenocytes.

Bulletin of experimental biology and medicine2002PMID: 12447482

Animal StudyIn VitroEpitalon

Plain Language Summary

Epitalon and Vilon activated interleukin-2 gene expression in mouse spleen cells without needing any other immune stimulants. The intensity of the effect depended on the peptide type, concentration, and duration of exposure, with both Epitalon and Vilon being more potent activators than the related peptide Cortagen.

Abstract

Synthetic peptides Vilon (Lys-Glu), Epithalon (Ala-Glu-Asp-Gly), and Cortagen (Ala-Glu-Asp-Pro) in vitro activated interleukin-2 mRNA synthesis in splenocytes from CBA mice in the absence of specific inductors. The intensity of interleukin-2 mRNA synthesis in splenocytes depended on the type, concentration, and duration of treatment with the peptides. Vilon and Epithalon were most potent, while Cortagen produced a less pronounced effect on interleukin-2 mRNA synthesis.

Authors

Kazakova, T B; Barabanova, S V; Khavinson, V Kh; Glushikhina, M S; Parkhomenko, E P; Malinin, V V; Korneva, E A